| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| Other Sizes |
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Diethylnorspermine 4HCl (DENSPM, BE-333), the tetrahydrochloride salt of Diethylnorspermine, is a potent inducer of spermidine/spermine N1-acetyltransferase, which is a polyamine catabolic enzyme. It is a polyamines analog that is able to induce cell cycle arrest, inhibit proliferation and induce apoptosis in melanoma, breast, prostate, lung and colon cancer cells.
| Molecular Formula |
C13H32N4
|
|---|---|
| Molecular Weight |
244.43
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| Exact Mass |
388.169
|
| CAS # |
156886-85-0
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| Related CAS # |
N1,N11-Diethylnorspermine;121749-39-1
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| PubChem CID |
11501988
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| Appearance |
White to off-white solid powder
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| Hydrogen Bond Donor Count |
8
|
| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
14
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| Heavy Atom Count |
21
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| Complexity |
117
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
LAWBSOKBIROCQP-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C13H32N4.4ClH/c1-3-14-8-5-10-16-12-7-13-17-11-6-9-15-4-2;;;;/h14-17H,3-13H2,1-2H3;4*1H
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| Chemical Name |
N-ethyl-N'-[3-[3-(ethylamino)propylamino]propyl]propane-1,3-diamine;tetrahydrochloride
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| Synonyms |
BE-333 HCl BE333 HClBE 333 HCl DE333 BE 3-3-3 BE-333 tetrahydrochloride DE-333DE 333 BE333BE 333 BE-333N(1),N(11)-DiethylnorspermineDENSPMBENSPM N1,N11-Bis(ethyl)norspermineDiethyl-norspermine N1,N11-Diethylnorspermine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~33.33 mg/mL (~85.40 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (256.24 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.0912 mL | 20.4558 mL | 40.9115 mL | |
| 5 mM | 0.8182 mL | 4.0912 mL | 8.1823 mL | |
| 10 mM | 0.4091 mL | 2.0456 mL | 4.0912 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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