| Size | Price | Stock | Qty |
|---|---|---|---|
| 5g |
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| Other Sizes |
| Targets |
Dicaprylyl carbonate does not target a specific biological receptor; rather, it functions as a cosmetic ingredient. It acts as an emollient by forming a thin film on the skin, reducing water loss, and imparting a smooth, non-greasy feel. It can also function as a solvent for other active ingredients, enhancing their skin penetration. Its target is the stratum corneum of the skin, where it interacts with lipids to improve barrier function and texture.
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|---|---|
| ln Vitro |
Octyl carbonate has a gloss value of 389.8. The surface quality of dioctyl carbonate is evaluated as matte to smooth [2].
In vitro, dicaprylyl carbonate is used in cosmetic formulations to assess its sensory properties and skin compatibility. It is tested for cytotoxicity on skin cells (e.g., keratinocytes, fibroblasts) and is generally found to be non-irritating and non-sensitizing. It does not show significant antimicrobial activity. Its compatibility with various active ingredients (e.g., UV filters, antioxidants) is evaluated in formulation studies. |
| ln Vivo |
In vivo, dicaprylyl carbonate is used in cosmetic products applied topically. It is well-tolerated and does not penetrate deeply into the skin, remaining on the surface where it performs its moisturizing and texturizing functions. It is not intended for systemic absorption; its safety has been evaluated in clinical use, and it is considered safe for topical application.
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| Enzyme Assay |
In vitro enzyme/receptor binding assays are not applicable to dicaprylyl carbonate, as it is not a bioactive compound. Its safety and efficacy are assessed through standard dermal tests, such as the Draize skin irritation test on reconstructed human epidermis. It is also tested for photostability and oxidative stability in formulation.
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| Cell Assay |
In vitro cellular experiments for dicaprylyl carbonate involve assessing its cytotoxicity using human dermal fibroblasts or keratinocytes. Cells are exposed to various concentrations of the compound (0.1-10%) for 24-72 hours, and cell viability is measured by MTT or neutral red uptake. The compound is generally found to be non-cytotoxic, with IC₅₀ > 100 µg/mL. Its effect on skin barrier function can be studied using 3D skin models.
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| Animal Protocol |
In vivo animal studies for dicaprylyl carbonate are typically limited to acute and subchronic dermal toxicity tests. In rabbits, it is applied to shaved skin for 24 hours, and irritation is scored. No significant irritation or sensitization is observed. A 28-day repeated-dose study in rats with dermal application showed no systemic toxicity. Standard safety tests confirm its low toxicity and safety for cosmetic use.
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| ADME/Pharmacokinetics |
The pharmacokinetic properties of dicaprylyl carbonate are not relevant, as it is not absorbed systemically in significant amounts. When applied topically, it is mostly retained on the skin surface. The small fraction that may penetrate the stratum corneum is rapidly metabolized by esterases to carbonic acid and 2-ethylhexanol, which are further metabolized and excreted. Systemic exposure is negligible.
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| Toxicity/Toxicokinetics |
The toxicity profile of dicaprylyl carbonate is favorable. It is non-toxic, non-irritating, and non-sensitizing. In acute oral studies, the LD₅₀ in rats is > 5000 mg/kg. In dermal studies, no irritation or sensitization has been reported. It is not a mutagen or reproductive toxicant. It has been reviewed by the Cosmetic Ingredient Review (CIR) Expert Panel and is considered safe for use in cosmetics at concentrations up to 100%.
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| References | |
| Additional Infomation |
Dicaprylyl carbonate is a widely used cosmetic ingredient, serving as an emollient, solvent, and texture enhancer. Its excellent spreading and skin-compatible properties make it popular in creams, lotions, and sunscreens. It is considered safe and is approved for use in many countries. It is not a drug but a functional ingredient in personal care products, contributing to the sensory experience and moisturization of the skin.
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| Molecular Formula |
C17H30O5
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|---|---|
| Molecular Weight |
314.4171
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| Exact Mass |
286.251
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| CAS # |
1680-31-5
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| PubChem CID |
9904000
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| Appearance |
Colorless to light yellow liquid
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| Density |
0.898g/cm3
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| Boiling Point |
350.886ºC at 760 mmHg
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| Melting Point |
-18℃
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| Flash Point |
134.694ºC
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| Vapour Pressure |
0mmHg at 25°C
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| Index of Refraction |
1.442
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| LogP |
5.86
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
16
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| Heavy Atom Count |
20
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| Complexity |
184
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CCCCCCCC(OC(OC(CCCCCCC)=O)=O)=O
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| InChi Key |
PKPOVTYZGGYDIJ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C17H34O3/c1-3-5-7-9-11-13-15-19-17(18)20-16-14-12-10-8-6-4-2/h3-16H2,1-2H3
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| Chemical Name |
dioctyl carbonate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 12.5 mg/mL (~43.64 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.25 mg/mL (4.36 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 1.25 mg/mL (4.36 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 1.25 mg/mL (4.36 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1805 mL | 15.9023 mL | 31.8046 mL | |
| 5 mM | 0.6361 mL | 3.1805 mL | 6.3609 mL | |
| 10 mM | 0.3180 mL | 1.5902 mL | 3.1805 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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