Size | Price | Stock | Qty |
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100mg |
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250mg |
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500mg |
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1g |
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2g |
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5g |
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10g |
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Other Sizes |
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Purity: ≥98%
Dexamethasone Phosphate disodium, the water-soluble salt form of dexamethasone administered through i.v. injection, is a potent synthetic glucocorticoid class of steroid drugs, and an interleukin receptor modulator with anti-inflammatory and immunosuppressive activities. Dexamethasone has anti-inflammatory and immunosuppressant effects. It is 25-fold more potent than cortisol in its glucocorticoid effect, while having minimal mineralocorticoid effect. Dexamethasone is used for the treatment of many conditions including: rheumatologic problems, a number of skin diseases such as erythema multiforme, severe allergies, asthma.
ln Vitro |
Dexamethasone disodium phosphate promotes the activation and inhibition of important genes involved in regulatory responses by regulating a number of regulatory factors, such as activator protein-1, nuclear factor-AT, and nuclear factor-kB [1]. With an EC50 of 2.2 nM, dexamethasone disodium phosphate efficiently controls the release of granulocyte-macrophage colony-stimulating factor (GM-CSF) from A549 cells. At 10-100 times greater concentrations, dexamethasone disodium phosphate (EC50=36 nM) inhibits the release of GM-CSF via sensing β2 infrared receptors and attaching to the DNA of the glucose signal receiving hormone (GR). The inhibition of GM-CSF release is linked to the inhibition of 3×κB (NF-κB, IκBα, and I-κBβ) by dexamethasone disodium phosphate (IC50=0.5 nM) [2].
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ln Vivo |
Lipopolysaccharide (LPS)-induced receptors were successfully suppressed by treatment with dexamethasone disodium phosphate at a dose of 2 × 5 mg/kg. When mice were exposed to lipopolysaccharide (LPS) and given a single injection of dexamethasone disodium phosphate (10 mg/kg (ip)), it resulted in a significant decrease in both granulocyte recruitment and oxygen freedom in our experimental system. revolutionaries emerging on their own initiative. One hour prior to and one hour following LPS inhalation, the effect was statistically significant. When water aerosols are administered to healthy animals, the number of granulocytes in BALF drops to values similar to those of those animals [3]. In comparison to the chart, rats treated with dexamethasone disodium phosphate devoured less food and weighed less. Even though the dosage of dexamethasone disodium phosphate injections was within food guidelines, the five-day injection period led to notable increases in liver mass (+42%) and liver-to-body weight (+65%). After 5 days of therapy, the muscles of the gastrocnemius were identical, but the animals' body weight was also reduced compared to those fed chow. Wet weight dropped by 20%, but relative weight remained exactly the same (g/100 g body weight), suggesting that weight reduction following surgery was coordinated with weight loss [4].
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References |
[1]. LaLone CA, et al. Effects of a glucocorticoid receptor agonist, Dexamethasone, on fathead minnow reproduction, growth, and development. Environ Toxicol Chem. 2012 Mar;31(3):611-22.
[2]. Adcock IM, et al. Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement. Br J Pharmacol. 1999 Jun;127(4):1003-11. [3]. Rocksén D, et al. Differential anti-inflammatory and anti-oxidative effects of Dexamethasone and N-acetylcysteine in endotoxin-induced lung inflammation. Clin Exp Immunol. 2000 Nov;122(2):249-56. [4]. Roussel D, et al. Dexamethasone treatment specifically increases the basal proton conductance of rat liver mitochondria. FEBS Lett. 2003 Apr 24;541(1-3):75-9 |
Molecular Formula |
C22H28FNA2O8P
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Molecular Weight |
516.4097
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CAS # |
2392-39-4
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Related CAS # |
Dexamethasone;50-02-2;Dexamethasone acetate;1177-87-3;Dexamethasone phosphate;312-93-6
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SMILES |
C[C@@]12[C@](C(COP([O-])([O-])=O)=O)(O)[C@H](C)C[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C2)=O.[Na+].[Na+]
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InChi Key |
PLCQGRYPOISRTQ-FCJDYXGNSA-L
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InChi Code |
InChI=1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30)/q2*+1/p-2/t12-,15+,16+,17+,19+,20+,21+,22+/m1../s1
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Chemical Name |
sodium 2-((8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl phosphate
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Synonyms |
Dexamethasone 21-phosphate disodium EGP-437 EGP 437 EGP437 Dex-Phos.
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O : ≥ 100 mg/mL (~193.65 mM)
DMSO : ~1 mg/mL (~1.94 mM) |
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Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (193.65 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.9364 mL | 9.6822 mL | 19.3645 mL | |
5 mM | 0.3873 mL | 1.9364 mL | 3.8729 mL | |
10 mM | 0.1936 mL | 0.9682 mL | 1.9364 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.