Deschloro Cetirizine DiHCl is an impurity in Cetirizine. Cetirizine is a second-generation antihistamine, a carboxylated metabolite of hydroxyzine, and a specific, orally bioactive, long-acting histamine H1-receptor blocker (antagonist).
Deschloro Cetirizine diHCl is an impurity and related substance of Cetirizine, a second-generation antihistamine. Deschloro Cetirizine lacks the chloro group present on the parent drug. It is used as a reference standard for pharmaceutical impurity profiling, quality control, and analytical method validation for Cetirizine drug substance and products. Target: Histamine H1 Receptor (indirectly, as an impurity standard). Cetirizine is a specific, orally active, long-acting histamine H1-receptor antagonist. Deschloro Cetirizine is expected to retain some H1 antagonist activity, but its primary use is as a pharmaceutical impurity standard rather than an active pharmacological agent. No in vitro activity data are reported for Deschloro Cetirizine as a pure compound. It is presumed to have lower potency at the H1 receptor compared to Cetirizine due to the removal of the chloro group. Not applicable, as it is not intended for in vivo efficacy studies. As an impurity, it is not used in animal models for therapeutic assessment. For cell-free impurity analysis by HPLC: Deschloro Cetirizine diHCl reference standard is dissolved in mobile phase (e.g., phosphate buffer/acetonitrile) at 0.1-1 mg/mL. The solution is injected into an HPLC system equipped with a C18 column (e.g., 250×4.6 mm, 5 um). UV detection is performed at 230 nm. The retention time is compared to Cetirizine peak for impurity identification and quantitation. No cell-based assays are performed. The compound is an analytical standard, not intended for biological evaluation. No animal studies are conducted. Deschloro Cetirizine is used for analytical quality control of Cetirizine drug products, not for in vivo experimentation. PK properties are not reported for Deschloro Cetirizine. As a dechlorinated analog of Cetirizine, it is expected to have similar but not identical pharmacokinetic properties: oral absorption likely preserved, moderate plasma protein binding (~90%), and renal excretion of unchanged drug. Not applicable. As a pharmaceutical impurity, it is not administered as a drug. Safety profile is not established. Cetirizine has a well-established safety profile with mild CNS effects (somnolence in some patients). Deschloro Cetirizine is considered for quality control purposes only. Deschloro Cetirizine diHCl is a pharmaceutical reference standard, not an active drug substance. It is not FDA-approved for therapeutic use. It is used as an impurity standard for Cetirizine in pharmaceutical quality control and for EP/JP/USP impurity method development. Cetirizine is an over-the-counter (OTC) antihistamine approved for allergic rhinitis and urticaria.

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.