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    Dehydroepiandrosterone (DHEA)
    Dehydroepiandrosterone (DHEA)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1733
    CAS #: 53-43-0Purity ≥98%

    Description: Dehydroepiandrosterone (trans-Dehydroandrosterone; DHEA; Prasterone; Psicosterone; EL-10; GL-701; IP-1001; NSC-9896; PB-007; SH-K-04828; Androstenolone; Diandrone) is an endogenous steroidal hormone acting as an androgen receptor antagonist and an estrogen receptor agonist. DHEA is acts as a metabolic intermediate in the biosynthesis of estrogen and androgen. Also, DHEA has a variety of potential biological effects by binding to nuclear and cell surface receptors and acts as a neurosteroid. DHEA significantly increased neural stem cells growth when grew with leukemia inhibitory factor and EGF. 

    References: Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1852-7; Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4678-83.


    Publications Citing Use of InvivoChem Dehydroepiandrosterone (DHEA)Reprod Biol. 2022 Jul 26;22(3):100671. doi: 10.1016/j.repbio.2022.100671.


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    Molecular Weight (MW)288.43
    FormulaC19H28O2 
    CAS No.53-43-0
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 57 mg/mL (197.6 mM)
    Water: <1 mg/mL
    Ethanol: 57 mg/mL (197.6 mM)
    Other info

    Chemical Name: (3S,8R,9S,10R,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-17H-cyclopenta[a]phenanthren-17-one

    InChi Key: FMGSKLZLMKYGDP-USOAJAOKSA-N

    InChi Code: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1

    SMILES Code: C[[email protected]]1([[email protected]](CC2)([H])[[email protected]]3([H])CC=C4C[[email protected]@H](O)CC[[email protected]]4(C)[[email protected]@]3([H])CC1)C2=O

    Synonyms

    NSC 9896; Prasterone; Psicosterone; DHEA; EL-10; GL-701; EL10; GL701; EL 10; GL 701; IP-1001; NSC-9896; IPL1001; NSC 896; IPL 1001; PB-007; SH-K-04828; Androstenolone; Diandrone; 


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    In Vitro

    In vitro activity: Dehydroepiandrosterone reversibly blocks GABA-induced currents, behaving as an allosteric antagonist of the GABAA receptor in cultured neurons from ventral mesencephalon. Dehydroepiandrosterone (DHEA) protects primary hippocampal cultures from embryonic day 18 (E18) embryos against NMDA-induced toxicity, DHEAS also reduces NMDA-induced toxicity. DHEA (100 nM) protects cultured neurons against the neurotoxic actions of either AMPA (25 mM) or kainic acid (1 mM) as well. Dehydroepiandrosterone (DHEA) increases the length of neurites containing the axonal marker Tau-1 in primary cultures of mouse embryonic neocortical neurons, and the incidence of varicosities and basket-like process formations in a dose-dependent fashion. Dehydroepiandrosterone (DHEA) rapidly increases free intracellular calcium via activation of N-methyl-D-aspartate (NMDA) receptors. Dehydroepiandrosterone with H874Y stimulates a 3- to 8-fold greater response than with wild type AR and at 100 nM the response is similar with the LNCaP mutant in the androgen-dependent human prostate cancer xenograft CWR22 and LNCaP cells.


    Cell Assay: Treatment of T. crassiceps with DHEA decreasd reproduction, motility and viability in a dose- and time-dependent fashion. Moreover, Pre-treatment with DHEA (10–100 nM for 6–8 h) protected hippocampal neurons against excitatory amino acid (0.1, 1, 10, and 50 mM)-induced neurotoxicity in vitro.

    In VivoDehydroepiandrosterone increases the number of newly formed cells in the dentate gyrus of the hippocampus of adult male rats, and also antagonizes the suppressive of corticosterone (40 mg/kg body weight daily for 5 days). Dehydroepiandrosterone by itself increases the number of newly formed neurons, but only if treatment is continued throughout the period of survival.
    Animal modelOvarian cortical autograft (‘normograft’) model; or rats model 
    Formulation & DosageDHEA dissolved in sesame oil; single rod implants (length 5 cm, diameter 3.35 mm); s.c administration. 
    References

    Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1852-7; Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4678-83.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Dehydroepiandrosterone (DHEA)

    The effect of DHEA on the survival of cells in hippocampal primary cultures exposed to NMDA.
    Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1852-7.
     

    Dehydroepiandrosterone (DHEA)

    Graph showing the effect of changing the time of application of either DHEA or DHEAS relative to that of NMDA (1 mM) on neuronal survival. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1852-7.
     

    Dehydroepiandrosterone (DHEA)


    The effects of DHEA on the lesions induced by NMDA infused into the hippocampus of rats. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1852-7.


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