| Size | Price | Stock | Qty |
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| 10mg |
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| 50mg |
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| 100mg | |||
| 250mg | |||
| 500mg | |||
| Other Sizes |
| Targets |
Decanoylevocarnitine targets the mitochondrial fatty acid oxidation pathway. It functions as an acylcarnitine that transports medium-chain fatty acids, like decanoate, into the mitochondrial matrix for β-oxidation via the carnitine shuttle. By facilitating fatty acid entry into the mitochondria, it plays a central role in energy metabolism. Its levels are associated with altered energy metabolism and mitochondrial dysfunction in conditions such as insulin resistance and heart failure.
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| ln Vitro |
In vitro, decanoylevocarnitine has a stimulatory effect on the formation of desaturated fatty acid metabolites from both [1-14C]-22:4 (n-6) and [1-14C]-22:5 (n-3). It increases the formation of C24 fatty acid intermediates, as well as docosapentaenoic and docosahexaenoic acid in rat hepatocytes. It is used in studies to assess fatty acid oxidation and as a standard in analytical methods for detecting acylcarnitines.
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| ln Vivo |
In vivo, decanoylevocarnitine is a normal metabolite present in the body. Abnormal increases in decanoylevocarnitine in rodent models are associated with reduced cardiac efficiency and impaired glucose utilization, supporting its role as both a metabolic intermediate and a pathophysiological indicator. It accumulates in models of impaired β-oxidation, insulin resistance, and heart failure, where elevated plasma and tissue levels correlate with altered energy metabolism and mitochondrial dysfunction.
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| Enzyme Assay |
In vitro assays for decanoylevocarnitine are typically analytical, using methods like mass spectrometry to measure its levels. It can be used as a substrate or standard in enzyme assays to study the activity of enzymes involved in fatty acid metabolism, such as carnitine palmitoyltransferase. Its effects on fatty acid desaturation can be assessed by incubating rat hepatocytes with radiolabeled fatty acid precursors and measuring the formation of desaturated metabolites.
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| Cell Assay |
For cell-based studies, decanoylevocarnitine can be added to the culture medium of hepatocytes or other cell lines to study its effects on fatty acid oxidation and metabolism. Cells are treated with the compound at various concentrations, and the formation of fatty acid metabolites is measured using radiometric or chromatographic methods. It is also used as a supplement in cell culture media for metabolic studies.
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| Animal Protocol |
In vivo, decanoylevocarnitine is a naturally occurring metabolite. It is not typically administered as a therapeutic agent in animal studies but is measured as a biomarker. In rodent models of metabolic disorders, plasma and tissue levels of decanoylevocarnitine are quantified to assess alterations in fatty acid oxidation and mitochondrial function.
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| ADME/Pharmacokinetics |
Decanoylevocarnitine (MW 315.45, C₁₇H₃₃NO₄) is a medium-chain acylcarnitine. It is a white to off-white solid powder. The compound is soluble in DMSO (100 mg/mL). It is typically stored as a powder at -20°C for long-term stability. Detailed pharmacokinetic parameters are not extensively reported as it is an endogenous metabolite.
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| Toxicity/Toxicokinetics |
Decanoylevocarnitine is an endogenous metabolite and is generally considered to be safe at normal physiological levels. However, elevated levels are associated with metabolic disorders and may indicate mitochondrial dysfunction. It is for research use only and is not intended for human therapeutic applications.
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| References |
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| Additional Infomation |
O-decanoyl-L-carnitine is an O-acyl-L-carnitine, specifically an L-carnitine with a decanoyl group as the acyl substituent. It is a human metabolite. It is an O-decanoylcarnitine, and also a saturated fatty acyl-L-carnitine and a medium-chain fatty acyl-L-carnitine. It has been reported that O-decanoyl-L-carnitine is present in the Chinese honeybee (Apis cerana), and relevant data exists.
Decanoylevocarnitine is a research compound used to study fatty acid metabolism and as a potential biomarker for metabolic disorders. It is not a drug and has no clinical applications. It is commercially available from various chemical suppliers for research purposes only. Its role in the carnitine shuttle makes it a valuable tool for investigating energy metabolism and mitochondrial function. |
| Molecular Formula |
C17H33NO4
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|---|---|
| Molecular Weight |
315.45
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| Exact Mass |
315.24
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| CAS # |
3992-45-8
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| PubChem CID |
11953821
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| Appearance |
White to off-white solid powder
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| LogP |
0.1
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
13
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| Heavy Atom Count |
22
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| Complexity |
318
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| Defined Atom Stereocenter Count |
1
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| SMILES |
CCCCCCCCCC(=O)O[C@H](CC(=O)[O-])C[N+](C)(C)C
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| InChi Key |
LZOSYCMHQXPBFU-OAHLLOKOSA-N
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| InChi Code |
InChI=1S/C17H33NO4/c1-5-6-7-8-9-10-11-12-17(21)22-15(13-16(19)20)14-18(2,3)4/h15H,5-14H2,1-4H3/t15-/m1/s1
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| Chemical Name |
(3R)-3-decanoyloxy-4-(trimethylazaniumyl)butanoate
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| Synonyms |
(-)-Decanoylcarnitine; Decanoyllevocarnitine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~317.01 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.93 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.93 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (7.93 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1701 mL | 15.8504 mL | 31.7007 mL | |
| 5 mM | 0.6340 mL | 3.1701 mL | 6.3401 mL | |
| 10 mM | 0.3170 mL | 1.5850 mL | 3.1701 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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