Decanedioic acid does not have a specific biological target. It is a metabolic intermediate in the oxidation of fatty acids and is used as a chemical intermediate. The compound is a dicarboxylic acid that can participate in various chemical reactions including esterification, amidation, and polymerization. It is not used as a pharmacologically active compound.

In vitro, decanedioic acid is used as a chemical reagent and intermediate in organic synthesis. Its reactivity is characterized by its two carboxyl groups, which can form esters, amides, and salts. The compound is not typically evaluated for biological activity as it is not a drug candidate. It is used in the production of polymers and as a plasticizer.

In vivo, decanedioic acid is a naturally occurring metabolic intermediate. It is formed during the beta-oxidation of fatty acids and can be further metabolized. The compound is not used therapeutically and is not administered for pharmacological purposes. Its biological role is primarily as a metabolic intermediate in lipid metabolism.

In vitro enzyme/receptor binding assays are not typically performed for decanedioic acid, as it is not a bioactive compound. The compound is used as a chemical intermediate and reagent in organic synthesis. Its purity and chemical properties are characterized by standard analytical techniques including NMR, HPLC, and GC rather than by biological assays.

In vitro cell-based assays are not applicable for decanedioic acid as it is not a pharmacologically active compound. The compound is used in chemical synthesis and is not evaluated for its effects on cell viability, proliferation, or other cellular functions. It is not intended for use in cell culture or biological research applications.

In vivo animal studies are not performed for decanedioic acid as it is not a pharmacologically active compound. The compound is used as a chemical intermediate and is not intended for therapeutic use. Any animal studies involving this compound would be limited to toxicological evaluations for occupational safety or environmental impact.

Decanedioic acid has a molecular formula of C10H18O4 and a molecular weight of 202.25. It is a white crystalline powder that is soluble in organic solvents and slightly soluble in water. The compound is stored at room temperature. Its melting point is approximately 130-134°C. The compound is used as a chemical intermediate in various industrial applications.

Toxicity Data
LC50 (Rat) > 4,500 mg/m3
The toxicity profile of decanedioic acid is favorable for industrial use. The compound has low acute toxicity and is not considered genotoxic or carcinogenic at relevant exposure levels. It may cause skin and eye irritation upon contact. Appropriate safety precautions should be taken during handling. The compound is not classified as a hazardous substance at typical use concentrations.

[1]. Sebacic acid binding to human plasma albumin. Biochem Pharmacol. 1993 Feb 9;45(3):697-702.

Sebacic acid is a white granular powder with a melting point of 153 °F (68 °C). It is slightly soluble in water. When heated to its melting point, it slowly sublimes under a pressure of 750 mmHg. Sebacic acid is an α,ω-dicarboxylic acid, a 1,8-dicarboxylic acid derivative of octane. It is a metabolite in both humans and plants. It is an α,ω-dicarboxylic acid and also a dicarboxylic acid fatty acid. It is the conjugate acid of sebacic acid (2-) and sebacic acid. It is derived from the hydride of decane. Sebacic acid has been reported in Drosophila melanogaster, Drosophila melanogaster, and other organisms with relevant data. Sebacic acid is a saturated, straight-chain, naturally occurring dicarboxylic acid containing 10 carbon atoms. Sebacic acid is a normal uric acid. Polyacyl-CoA dehydrogenase deficiency (MADD) or glutamateuria type II (GAII) is a group of metabolic disorders caused by a deficiency of electron transport flavoprotein or electron transport flavoprotein ubiquinone oxidoreductase. In these patients, biochemical data showed increased urinary sebacic acid excretion. Sebacic acid is a white, flaky or powdery crystalline solid, slightly soluble in water, and has been proposed as an alternative energy substrate for total parenteral nutrition. The Latin name for sebacic acid, "sebaceus" (meaning "butter candle") or "sebum" (meaning "butter"), derives from its use in candle making. Sebacic acid and its derivatives, such as azelaic acid, have wide industrial applications, serving as plasticizers, lubricants, hydraulic fluids, cosmetics, and candles. It is also used in the synthesis of polyamides and alkyd resins and as an intermediate in fragrances, preservatives, and coatings. (A7916, A7917, A7918, A7919).
See also: Polifeprosan 20 (monomer)...See more...
Decanedioic acid is a naturally occurring dicarboxylic acid also known as sebacic acid. It is found naturally in castor oil and is used as a chemical intermediate in the production of polymers, plastics, lubricants, and pharmaceuticals. The compound is a metabolic intermediate in the oxidation of fatty acids. It is used for research and industrial purposes.

C10H18O4

202.2475

202.12

111-20-6

Decanedioic acid-d4;339080-77-2;Decanedioic acid-d16;73351-71-0

5192

White to off-white solid powder

1.1±0.1 g/cm3

374.3±0.0 °C at 760 mmHg

274.1 °F (NTP, 1992)
130.8 °C
131 °C

198.3±19.7 °C

0.0±1.8 mmHg at 25°C

1.475

2.1

2

4

9

14

157

0

O([H])C(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)O[H])=O

CXMXRPHRNRROMY-UHFFFAOYSA-N

InChI=1S/C10H18O4/c11-9(12)7-5-3-1-2-4-6-8-10(13)14/h1-8H2,(H,11,12)(H,13,14)

decanedioic acid

Acide sebacique; 1,10-Decanedioic acid; Decanedioic acid

2934.99.9001

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

DMSO : ≥ 100 mg/mL (~494.44 mM)
H2O : ~1 mg/mL (~4.94 mM)

Solubility in Formulation 1: ≥ 2.5 mg/mL (12.36 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL.
Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.

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Solubility in Formulation 2: ≥ 2.5 mg/mL (12.36 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.

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Solubility in Formulation 3: ≥ 2.5 mg/mL (12.36 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.

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 (Please use freshly prepared in vivo formulations for optimal results.)