| Size | Price | |
|---|---|---|
| Other Sizes |
| Toxicity/Toxicokinetics |
Toxicity Data
LC50 (Rat) > 4,500 mg/m3 |
|---|---|
| References | |
| Additional Infomation |
Sebacic acid is a white granular powder with a melting point of 153 °F (68 °C). It is slightly soluble in water. When heated to its melting point, it slowly sublimes under a pressure of 750 mmHg. Sebacic acid is an α,ω-dicarboxylic acid, a 1,8-dicarboxylic acid derivative of octane. It is a metabolite in both humans and plants. It is an α,ω-dicarboxylic acid and also a dicarboxylic acid fatty acid. It is the conjugate acid of sebacic acid (2-) and sebacic acid. It is derived from the hydride of decane. Sebacic acid has been reported in Drosophila melanogaster, Drosophila melanogaster, and other organisms with relevant data. Sebacic acid is a saturated, straight-chain, naturally occurring dicarboxylic acid containing 10 carbon atoms. Sebacic acid is a normal uric acid. Polyacyl-CoA dehydrogenase deficiency (MADD) or glutamateuria type II (GAII) is a group of metabolic disorders caused by a deficiency of electron transport flavoprotein or electron transport flavoprotein ubiquinone oxidoreductase. In these patients, biochemical data showed increased urinary sebacic acid excretion. Sebacic acid is a white, flaky or powdery crystalline solid, slightly soluble in water, and has been proposed as an alternative energy substrate for total parenteral nutrition. The Latin name for sebacic acid, "sebaceus" (meaning "butter candle") or "sebum" (meaning "butter"), derives from its use in candle making. Sebacic acid and its derivatives, such as azelaic acid, have wide industrial applications, serving as plasticizers, lubricants, hydraulic fluids, cosmetics, and candles. It is also used in the synthesis of polyamides and alkyd resins and as an intermediate in fragrances, preservatives, and coatings. (A7916, A7917, A7918, A7919).
See also: Polifeprosan 20 (monomer)...See more... |
| Molecular Formula |
C10H18O4
|
|---|---|
| Molecular Weight |
202.2475
|
| Exact Mass |
202.12
|
| CAS # |
111-20-6
|
| Related CAS # |
Decanedioic acid-d4;339080-77-2;Decanedioic acid-d16;73351-71-0
|
| PubChem CID |
5192
|
| Appearance |
White to off-white solid powder
|
| Density |
1.1±0.1 g/cm3
|
| Boiling Point |
374.3±0.0 °C at 760 mmHg
|
| Melting Point |
274.1 °F (NTP, 1992)
130.8 °C 131 °C |
| Flash Point |
198.3±19.7 °C
|
| Vapour Pressure |
0.0±1.8 mmHg at 25°C
|
| Index of Refraction |
1.475
|
| LogP |
2.1
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
9
|
| Heavy Atom Count |
14
|
| Complexity |
157
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O([H])C(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)O[H])=O
|
| InChi Key |
CXMXRPHRNRROMY-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C10H18O4/c11-9(12)7-5-3-1-2-4-6-8-10(13)14/h1-8H2,(H,11,12)(H,13,14)
|
| Chemical Name |
decanedioic acid
|
| Synonyms |
Acide sebacique; 1,10-Decanedioic acid; Decanedioic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~494.44 mM)
H2O : ~1 mg/mL (~4.94 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (12.36 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (12.36 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (12.36 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.9444 mL | 24.7219 mL | 49.4438 mL | |
| 5 mM | 0.9889 mL | 4.9444 mL | 9.8888 mL | |
| 10 mM | 0.4944 mL | 2.4722 mL | 4.9444 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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