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    DDR1-IN-1
    DDR1-IN-1

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1882
    CAS #: 1449685-96-4Purity ≥98%

    Description: DDR1-IN-1 is a potent and selective discoidin domain receptor 1 (DDR1) receptor tyrosine kinase inhibitor with IC50 of 105 nM, and is about 3-fold selectivity over DDR2. DDR1-IN-1 binds to DDR1 in the 'DFG-out' conformation and inhibits DDR1 autophosphorylation in cells at submicromolar concentrations with good selectivity as assessed against a panel of 451 kinases measured. DDR1-IN-1 provides a useful pharmacological probe for DDR1-dependent signal transduction. The DDR1 receptor tyrosine kinase is activated by matrix collagens and has been implicated in numerous cellular functions such as proliferation, differentiation, adhesion, migration, and invasion. 

    References: ACS Chem Biol. 2013 Oct 18;8(10):2145-50.

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    Molecular Weight (MW)552.59 
    FormulaC30H31F3N4O3 
    CAS No.1449685-96-4 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 100 mg/mL (181 mM)
    Water: <1 mg/mL
    Ethanol: 4 mg/mL (7.2 mM)
    Other info

    Chemical Name: 4-((4-ethylpiperazin-1-yl)methyl)-N-(4-methyl-3-(2-oxoindolin-5-yloxy)phenyl)-3-(trifluoromethyl)benzamide

    SMILES: FC(C1=CC(C(NC2=CC=C(C(OC3=CC(C4)=C(C=C3)NC4=O)=C2)C)=O)=CC=C1CN5CCN(CC)CC5)(F)F

    Synonyms

    DDR1-IN-1; DDR1-IN 1; DDR1-IN1


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