| Size | Price | Stock | Qty |
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| 10mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
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| ln Vivo |
In mice, dapirazole hydrochloride injections (once intraperitoneal or intravenous; 0–10 mg/kg or 0–3 mg/mouse) lessen the overall severity of opiate withdrawal symptoms [1].
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|---|---|
| Animal Protocol |
Animal/Disease Models: Swiss albino male CD-1 mouse, body weight 20 -25 g, acute dependence model [1]
Doses: 5, 7.5 and 10 mg/kg (ip) or 0.5, 1 and 3 mg/mouse (icv ), single Route of Administration: intraperitoneal (ip) injection or intracerebroventricular administration, single Experimental Results:diminished jumping behavior, head shaking, and paw shaking when administered before naloxone. |
| References | |
| Additional Infomation |
Dapiprazole Hydrochloride is an alpha-1-adrenergic antagonist that acts by blocking alpha-adrenergic receptors in the smooth muscle of blood vessels (arteries, arterioles and veins), gastrointestinal tract, and radial smooth muscle of the iris. This prevents smooth muscle contraction and results in vasodilatation. Administered in the eye, dapiprazole hydrochloride produces miosis. In the heart, it may antagonize alpha-1 adrenoreceptors in myocytes causing a mild negative inotropic effect.
See also: Dapiprazole (has active moiety). |
| Molecular Formula |
C19H27N5.HCL
|
|---|---|
| Molecular Weight |
361.91212
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| Exact Mass |
361.203
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| CAS # |
72822-13-0
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| Related CAS # |
Dapiprazole;72822-12-9
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| PubChem CID |
6917787
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| Appearance |
White to off-white solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
538.9±60.0 °C at 760 mmHg
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| Flash Point |
279.7±32.9 °C
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| Vapour Pressure |
0.0±1.4 mmHg at 25°C
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| Index of Refraction |
1.658
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| LogP |
2.44
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
25
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| Complexity |
395
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
ZIODNPFQZIHCOE-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C19H27N5.ClH/c1-16-6-2-3-7-17(16)23-14-12-22(13-15-23)11-9-19-21-20-18-8-4-5-10-24(18)19;/h2-3,6-7H,4-5,8-15H2,1H3;1H
|
| Chemical Name |
3-[2-[4-(2-methylphenyl)piperazin-1-yl]ethyl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine;hydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~100 mg/mL (~276.31 mM)
DMSO : ~12.5 mg/mL (~34.54 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (138.16 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7631 mL | 13.8156 mL | 27.6312 mL | |
| 5 mM | 0.5526 mL | 2.7631 mL | 5.5262 mL | |
| 10 mM | 0.2763 mL | 1.3816 mL | 2.7631 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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