| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
In enzymatic and cellular studies, D5D-IN-326 is a selective and potent oral delta-5 desaturase (D5D) inhibitor, with IC50 values of 72 and 22 nM for rat and human D5D, respectively, and for D6D or D9D. Exercise has no impact [1].
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| ln Vivo |
When given orally for six weeks, D5D-IN-326 (0.1, 1 and 10 mg/kg) progressively decreased body weight at the 10 mg/kg dose; however, in DIO mice, lesser doses were ineffective after six weeks of treatment [1]. Additionally, D5D-IN-326 (10 mg/kg, orally administered for 6 weeks) dramatically decreased the levels of Ccl2, Cd68, Adgre1, and Il6 gene expression, as well as the mRNA for epididymal Lep and Adipoq, which were significantly elevated in HFD DIO mice [1].
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| References |
| Molecular Formula |
C17H11F8N3O4
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|---|---|
| Molecular Weight |
473.274172067642
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| Exact Mass |
473.062
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| CAS # |
1236767-85-3
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| PubChem CID |
59416313
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| Appearance |
Pale purple to purple solid powder
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| LogP |
3.4
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
13
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
32
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| Complexity |
829
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| Defined Atom Stereocenter Count |
0
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| SMILES |
FC(C(F)(F)F)(COC1=NC2=C(C(N1C1C=CC(=CC=1)OCC(F)(F)F)=O)CC(N2)=O)F
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| InChi Key |
NGUQGJZXDBRNOL-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C17H11F8N3O4/c18-15(19,17(23,24)25)6-32-14-27-12-10(5-11(29)26-12)13(30)28(14)8-1-3-9(4-2-8)31-7-16(20,21)22/h1-4H,5-7H2,(H,26,29)
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| Chemical Name |
2-(2,2,3,3,3-pentafluoropropoxy)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-5,7-dihydropyrrolo[2,3-d]pyrimidine-4,6-dione
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~125 mg/mL (~264.12 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (4.39 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (4.39 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1130 mL | 10.5648 mL | 21.1296 mL | |
| 5 mM | 0.4226 mL | 2.1130 mL | 4.2259 mL | |
| 10 mM | 0.2113 mL | 1.0565 mL | 2.1130 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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