| Size | Price | Stock | Qty |
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| 1g |
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| 10g |
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| Other Sizes |
| Targets |
D-Pipecolinic acid does not have a specific pharmacological target. It may interact with GABA receptors or other neurotransmitter systems, but its biological activity is not well characterized. It is primarily used as a chemical intermediate and in research on lysine metabolism.
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|---|---|
| ln Vitro |
In vitro, D-pipecolinic acid has been studied for its effects on neurotransmitter systems, but specific activity data are limited. It may act as a weak agonist or antagonist at certain receptors. It is not a potent pharmacologically active compound.
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| ln Vivo |
In vivo, D-pipecolinic acid is a metabolite of lysine. It is present in biological fluids at low concentrations. It does not have significant pharmacological activity. It is not used as a therapeutic agent.
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| Enzyme Assay |
Pipecolinic acid can be analyzed by HPLC or GC-MS. Enzymatic assays using pipecolate oxidase can be used to measure pipecolinic acid levels. For use as a synthetic intermediate, standard organic chemistry reactions are employed.
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| Cell Assay |
D-Pipecolinic acid is not typically used in cell-based assays as a pharmacologically active agent. It may be used in metabolism studies or as a negative control.
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| Animal Protocol |
Animal studies are not applicable for D-pipecolinic acid as a therapeutic agent. It may be used in metabolic studies to trace lysine metabolism.
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| ADME/Pharmacokinetics |
D-Pipecolinic acid (MW 129.16) is a small hydrophilic molecule. It is metabolized via the pipecolate pathway. It is excreted in urine. Pharmacokinetic properties are not well characterized.
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| Toxicity/Toxicokinetics |
D-Pipecolinic acid is considered to have low toxicity. It is a naturally occurring metabolite. No significant toxicity has been reported.
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| Additional Infomation |
D-piperidinic acid is the D-enantiomer of piperidinic acid and plays a role in human metabolism. It is the conjugate base of D-piperidinic acid and also the enantiomer of L-piperidinic acid. (R)-piperidin-2-carboxylic acid has been reported in evening primrose (Lunaria annua), petalonia fascia, and acacia excelsa, and relevant data are available.
D-Pipecolinic acid is a research chemical used as a building block in organic synthesis and as a reference standard. It is not a drug and is not in clinical trials. It is the D-enantiomer of pipecolinic acid. |
| Molecular Formula |
C6H9NO2
|
|---|---|
| Molecular Weight |
127.141161680222
|
| Exact Mass |
129.078
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| CAS # |
1723-00-8
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| PubChem CID |
736316
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| Appearance |
White to off-white solid powder
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
265.8±33.0 °C at 760 mmHg
|
| Melting Point |
272ºC(lit.)
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| Flash Point |
114.5±25.4 °C
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| Vapour Pressure |
0.0±1.1 mmHg at 25°C
|
| Index of Refraction |
1.479
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| LogP |
-2.3
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| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
1
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| Heavy Atom Count |
9
|
| Complexity |
114
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
C1CCN[C@H](C1)C(=O)O
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| InChi Key |
HXEACLLIILLPRG-RXMQYKEDSA-N
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| InChi Code |
InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m1/s1
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| Chemical Name |
(2R)-piperidine-2-carboxylic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~66.67 mg/mL (~516.18 mM)
DMSO :< 1 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (774.23 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.8653 mL | 39.3267 mL | 78.6535 mL | |
| 5 mM | 1.5731 mL | 7.8653 mL | 15.7307 mL | |
| 10 mM | 0.7865 mL | 3.9327 mL | 7.8653 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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