| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| 1g |
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| Other Sizes |
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| ln Vitro |
Despite being in a competitive setting, Pyran can distinguish between distinct cations and Cu+ ions. Pyran can detect ions in environmental samples thanks to its micromolar detection limit and quick fluorescence response (t1/2=1.66 minutes) to Cu+ ions. Pyran and Cu+ have an observed complexation stoichiometry of 2:1[1]. The effectiveness of the pH-sensitive fluorescent indicator pyran as an intravital corneal and anterior chamber probe was investigated. Fluorophotometry can be used to measure the concentrations in the cornea and anterior chamber after topical application, which can take many hours to reach. The ratio of fluorescence intensities at two excitation wavelengths, I463/I404, is used to calculate pH. This ratio depends on pH but is unaffected by fluorophore concentration or other factors that could change intensity. Pyranosine in the cornea and anterior chamber of rabbit eyes showed readily quantifiable changes in fluorescence ratios in response to eyelid closure and contact lens wear, suggesting sensitivity to minute pH variations [2].
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| References |
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| Additional Infomation |
Pyranine is an organic sodium salt. It has a role as a fluorochrome. It contains a pyranine(3-). It derives from a hydride of a pyrene.
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| Molecular Formula |
C16H7NA3O10S3
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|---|---|
| Molecular Weight |
524.37
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| Exact Mass |
523.889
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| CAS # |
6358-69-6
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| PubChem CID |
61388
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| Appearance |
Light yellow to yellow solid powder
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| Density |
2.15
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| Boiling Point |
171-178 °C10 mm Hg(lit.)
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| Melting Point |
62-63.5 °C(lit.)
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| Flash Point |
250 °C
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| LogP |
4.244
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
10
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
32
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| Complexity |
932
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
KXXXUIKPSVVSAW-UHFFFAOYSA-K
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| InChi Code |
InChI=1S/C16H10O10S3.3Na/c17-11-5-12(27(18,19)20)8-3-4-10-14(29(24,25)26)6-13(28(21,22)23)9-2-1-7(11)15(8)16(9)10;;;/h1-6,17H,(H,18,19,20)(H,21,22,23)(H,24,25,26);;;/q;3*+1/p-3
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| Chemical Name |
trisodium;8-hydroxypyrene-1,3,6-trisulfonate
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| Synonyms |
Green No. 204; Green 204; D & C Green no. 8
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~20 mg/mL (~38.14 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 25 mg/mL (47.67 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with heating and sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9071 mL | 9.5353 mL | 19.0705 mL | |
| 5 mM | 0.3814 mL | 1.9071 mL | 3.8141 mL | |
| 10 mM | 0.1907 mL | 0.9535 mL | 1.9071 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT01000311 | Completed | Biological: MenACWY-CRM Biological: DTaP-IPV/Hib |
Meningococcal Disease | Novartis Vaccines | November 2009 | Phase 3 |
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