| Size | Price | Stock | Qty |
|---|---|---|---|
| 5g |
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| Other Sizes |
| ln Vivo |
- D-Arabinose exhibited dose-dependent growth inhibitory activity against the nematode Caenorhabditis elegans. At concentrations of 50, 100, 200 mM, it reduced the body length of C. elegans by 12%, 28%, and 45%, respectively, compared to the control group after 72 hours of treatment [1]
- It slowed down the growth rate of C. elegans: the time to reach the adult stage was prolonged by 18 hours (100 mM) and 32 hours (200 mM) [1] - The compound did not induce significant lethality in C. elegans even at 200 mM, with a survival rate maintained above 95% [1] |
|---|---|
| Animal Protocol |
- C. elegans culture and treatment: Wild-type C. elegans (N2 strain) were maintained on nematode growth medium (NGM) at 20°C. D-Arabinose was dissolved in distilled water and added to NGM to final concentrations of 25, 50, 100, 200 mM. Synchronized L1-stage larvae were transferred to the treated NGM plates [1]
- Growth and survival assessment: C. elegans body length was measured under a microscope at 24, 48, 72 hours post-treatment. Growth curves were plotted based on body length data. Survival rate was recorded daily for 10 days to evaluate lethality [1] |
| References | |
| Additional Infomation |
D-arabinopyranose is the pyranose form of D-arabinose. D-arabinopyranose has been reported in guava (Psidium guajava), and data are available. See also: L-arabinose (note moved here). - D-arabinose is a naturally occurring monosaccharide that has been identified as a novel bioactive compound with growth-inhibiting activity against Caenorhabditis elegans [1]. - Its growth-inhibiting mechanism may be related to interference with carbohydrate metabolism or energy homeostasis in Caenorhabditis elegans, but the exact molecular target has not been identified [1]. - Due to its selective growth inhibition and low lethality, D-arabinose shows potential as a candidate for developing environmentally friendly antiparasitic drugs [1].
|
| Molecular Formula |
C5H10O5
|
|---|---|
| Molecular Weight |
150.1299
|
| Exact Mass |
150.052
|
| CAS # |
28697-53-2
|
| Related CAS # |
L-(+)-Lyxose;1949-78-6;D-Arabinose-13C;D-Arabinose-13C-1;139657-60-6;D-arabinose-13C-2;D-Arabinose-13C-3;101615-87-6;D-Arabinose-d2;2419933-20-1;D-Arabinose-d5;D-Arabinose-d6
|
| PubChem CID |
6902
|
| Appearance |
White to off-white solid powder
|
| Density |
1.8±0.1 g/cm3
|
| Boiling Point |
333.2±42.0 °C at 760 mmHg
|
| Melting Point |
152-160ºC
|
| Flash Point |
155.3±27.9 °C
|
| Vapour Pressure |
0.0±1.6 mmHg at 25°C
|
| Index of Refraction |
1.646
|
| LogP |
-0.83
|
| Hydrogen Bond Donor Count |
4
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
0
|
| Heavy Atom Count |
10
|
| Complexity |
117
|
| Defined Atom Stereocenter Count |
3
|
| SMILES |
C1[C@H]([C@H]([C@@H](C(O1)O)O)O)O
|
| InChi Key |
SRBFZHDQGSBBOR-ZRMNMSDTSA-N
|
| InChi Code |
InChI=1S/C5H10O5/c6-2-1-10-5(9)4(8)3(2)7/h2-9H,1H2/t2-,3-,4+,5?/m1/s1
|
| Chemical Name |
(3S,4R,5R)-oxane-2,3,4,5-tetrol
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~666.09 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (16.65 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (16.65 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (16.65 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.6609 mL | 33.3045 mL | 66.6089 mL | |
| 5 mM | 1.3322 mL | 6.6609 mL | 13.3218 mL | |
| 10 mM | 0.6661 mL | 3.3304 mL | 6.6609 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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