| Size | Price | Stock | Qty |
|---|---|---|---|
| 5g |
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| Other Sizes |
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| ln Vitro |
Cysteine hydrochloride (2-aminoethanethiol hydrochloride) has been demonstrated to raise intracellular glutathione levels in cystine cells, thereby restoring the cell's redox state. The rise in cystine cell acidity rate is also assumed to be the result of increased activity of the caspase 3 and protein inhibitor Cε, which can be regulated by cysteamine hydrochloride. Cysteamine HCl has antioxidant effects due to enhanced glutathione synthesis. Cysteamine hydrochloride is an efficient OH and HOCl scavenger; it also reacts with H2O2. Cysteine hydrochloride has recently enhanced the synthesis of heat shock proteins (HSPs), particularly Hsp40. Modeling of doxorubicin-induced AIDS inactivation by cysteamine hydrochloride as evaluated in HeLa cells and B16 cells Additionally, addition of cysteamine hydrochloride to doxorubicin in doxorubicin-resistant breast cancer cell lines Amines generate a considerable increase in cell death [1]. Hydrochloric acid (100 μM) can greatly raise the intracellular GSH levels of cultured mature oocytes and sleep granules that grow to the blastocyst stage [2].
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|---|---|
| References | |
| Additional Infomation |
Cysteamine hydrochloride is an alkanethiol.
A mercaptoethylamine compound that is endogenously derived from the COENZYME A degradative pathway. The fact that cysteamine is readily transported into LYSOSOMES where it reacts with CYSTINE to form cysteine-cysteamine disulfide and CYSTEINE has led to its use in CYSTINE DEPLETING AGENTS for the treatment of CYSTINOSIS. See also: Cysteamine (has active moiety). Drug Indication Cystadrops is indicated for the treatment of corneal cystine crystal deposits in adults and children from 2 years of age with cystinosis. Treatment of corneal cystine crystal deposits in cystinosis |
| Molecular Formula |
C2H8CLNS
|
|---|---|
| Molecular Weight |
113.6096
|
| Exact Mass |
113.006
|
| CAS # |
156-57-0
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| Related CAS # |
Cysteamine-d4 hydrochloride;1219805-04-5
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| PubChem CID |
9082
|
| Appearance |
White to off-white solid powder
|
| Density |
0.75
|
| Boiling Point |
116.4ºC at 760 mmHg
|
| Melting Point |
67-71 °C
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| Flash Point |
24.2ºC
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| Vapour Pressure |
16.7mmHg at 25°C
|
| LogP |
1.377
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| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
1
|
| Heavy Atom Count |
5
|
| Complexity |
10
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
OGMADIBCHLQMIP-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C2H7NS.ClH/c3-1-2-4;/h4H,1-3H2;1H
|
| Chemical Name |
2-aminoethanethiol;hydrochloride
|
| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~880.20 mM)
H2O : ≥ 50 mg/mL (~440.10 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (18.31 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (18.31 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (18.31 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 100 mg/mL (880.20 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 8.8020 mL | 44.0102 mL | 88.0204 mL | |
| 5 mM | 1.7604 mL | 8.8020 mL | 17.6041 mL | |
| 10 mM | 0.8802 mL | 4.4010 mL | 8.8020 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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