| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| 100mg |
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| Other Sizes |
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| ln Vitro |
Cynaropicrin, with IC50 values of 8.24 and 3.18 μM, respectively, potently suppresses lipopolysaccharide-induced TNF-α production from human or murine macrophages in a dose-dependent manner. Cynaropicrin exhibited noteworthy suppression of all mitogenic signals, with IC50 values of 0.90 μM for lipopolysaccharide, 1.02 for phytohemagglutinin, and 1.20 for concanavalin A. The growth of CTLL-2 cells is inhibited by Cynaropicrin in a dose-dependent manner; its 50% inhibitory concentration (IC50) on CTLL-2 cell growth is 0.91 μM [1]. Cynaropicrin also suppressed the TNF-α-induced rise in MMP13 mRNA expression in a concentration-dependent manner. Cynaropicrin reduced the IL-1β-induced rise in HIF-2α mRNA expression in SW1353 in a concentration-dependent manner [2].
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| References |
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| Additional Infomation |
Cynaropicrin is a sesquiterpene lactone.
Cynaropicrin has been reported in Saussurea eopygmaea, Artemisia xerophytica, and other organisms with data available. See also: Cynara scolymus leaf (part of). |
| Molecular Formula |
C19H22O6
|
|---|---|
| Molecular Weight |
346.3744
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| Exact Mass |
346.142
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| CAS # |
35730-78-0
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| PubChem CID |
119093
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| Appearance |
Off-white to light yellow ointment
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| Density |
1.28g/cm3
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| Boiling Point |
566.2ºC at 760mmHg
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| Flash Point |
203.8ºC
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| LogP |
1.057
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
25
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| Complexity |
690
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| Defined Atom Stereocenter Count |
6
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| SMILES |
O1C(C(=C([H])[H])[C@]2([H])[C@]([H])(C([H])([H])C(=C([H])[H])[C@]3([H])C([H])([H])[C@@]([H])(C(=C([H])[H])[C@]3([H])[C@@]12[H])O[H])OC(C(=C([H])[H])C([H])([H])O[H])=O)=O
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| InChi Key |
KHSCYOFDKADJDJ-NQLMQOPMSA-N
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| InChi Code |
InChI=1S/C19H22O6/c1-8-5-14(24-18(22)9(2)7-20)16-11(4)19(23)25-17(16)15-10(3)13(21)6-12(8)15/h12-17,20-21H,1-7H2/t12-,13-,14-,15-,16+,17+/m0/s1
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| Chemical Name |
[(3aR,4S,6aR,8S,9aR,9bR)-8-hydroxy-3,6,9-trimethylidene-2-oxo-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-4-yl] 2-(hydroxymethyl)prop-2-enoate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 50 mg/mL (~144.35 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.22 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.22 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (7.22 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8871 mL | 14.4354 mL | 28.8709 mL | |
| 5 mM | 0.5774 mL | 2.8871 mL | 5.7742 mL | |
| 10 mM | 0.2887 mL | 1.4435 mL | 2.8871 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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