| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 25mg |
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| 50mg | |||
| Other Sizes |
Purity: ≥98%
| Targets |
Cyclopyrimorate targets homogentisate solanesyltransferase, a downstream enzyme of 4-hydroxyphenylpyruvate dioxygenase in the plastoquinone biosynthesis pathway. By inhibiting this enzyme, it disrupts plastoquinone biosynthesis, leading to bleaching and death of the weed. It is a pyridazine-class bleaching herbicide.
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| ln Vitro |
Decyl PQ can restore cyclopyrimidine-dependent bleaching in Arabidopsis thaliana, suggesting that this symptom is linked to suppression of PQ production [1].
Cyclopyrimorate is a novel and highly effective herbicide for weed control in rice fields. It acts by targeting homogentisate solanesyltransferase. It shows strong activity against a broad spectrum of annual and perennial weeds. |
| ln Vivo |
Cyclopyrimorate is used as a herbicide for weed control in rice cultivation. It shows strong activity against a broad spectrum of annual and perennial weeds while maintaining high selectivity and safety for rice crops.
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| Enzyme Assay |
Cyclopyrimorate is evaluated in cell-free enzymatic assays using purified HST. The compound is incubated with HST and a substrate, and the inhibition of enzyme activity is measured. IC50 values are determined to quantify the potency of HST inhibition.
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| Cell Assay |
Cyclopyrimorate is assessed in plant-based assays to measure its herbicidal activity. The compound is applied to weeds, and growth inhibition and bleaching are measured.
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| Animal Protocol |
Cyclopyrimorate is applied to rice fields in agricultural settings to evaluate its herbicidal efficacy and crop safety. It shows strong activity against weeds while maintaining high selectivity for rice crops.
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| ADME/Pharmacokinetics |
Cyclopyrimorate has a molecular weight of 389.83 and a molecular formula of C19H20ClN3O4. It has a CAS number of 499231-24-2. The compound is a solid. It should be stored at room temperature.
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| Toxicity/Toxicokinetics |
No detailed toxicity data is available for Cyclopyrimorate. The compound is a herbicide and is not intended for human therapeutic use. It is used in agricultural applications.
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| References | |
| Additional Infomation |
Cyclopyrimorate carbamates belong to the pyridazine class of compounds. They are compounds formed by substituting 3-chloropyridazine at the 5- and 6-positions with (morpholino-4-ylcarbonyl)oxy and 2-cyclopropyl-6-methylphenoxy, respectively. It is a selective herbicide used to control broadleaf and grass weeds in cereal and rice paddies. It has a dual function as a herbicide, agrochemical, and EC 2.5.1.117 (solanine transferase) inhibitor. It belongs to the pyridazine, carbamate, morpholino, aromatic ether, cyclopropane, and organochlorine compounds classes.
Cyclopyrimorate is a novel and highly effective bleaching herbicide for weed control in rice fields. It has a CAS number of 499231-24-2. It targets homogentisate solanesyltransferase. It is not approved for human therapeutic use. |
| Molecular Formula |
C19H20CLN3O4
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|---|---|
| Molecular Weight |
389.832803726196
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| Exact Mass |
389.114
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| CAS # |
499231-24-2
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| PubChem CID |
23013854
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| Appearance |
Off-white to light yellow solid powder
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| LogP |
3.877
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
27
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| Complexity |
515
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
BXIGJZDQFDFASM-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C19H20ClN3O4/c1-12-3-2-4-14(13-5-6-13)17(12)27-18-15(11-16(20)21-22-18)26-19(24)23-7-9-25-10-8-23/h2-4,11,13H,5-10H2,1H3
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| Chemical Name |
6-Chloro-3-(2-cyclopropyl-6-methylphenoxy)-4-pyridazinyl 4-morpholinecarboxylate
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| Synonyms |
SW-065 SW 065 SW065 H-965 H 965 H965
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~250 mg/mL (~641.31 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 6.25 mg/mL (16.03 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 62.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 6.25 mg/mL (16.03 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 62.5 mg/mL clear DMSO stock solution to 900 μL corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5652 mL | 12.8261 mL | 25.6522 mL | |
| 5 mM | 0.5130 mL | 2.5652 mL | 5.1304 mL | |
| 10 mM | 0.2565 mL | 1.2826 mL | 2.5652 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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