| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Cumic alcohol does not have a well-defined pharmacological target. It has insect repellent properties. It functions as a fragrance, an insect repellent, a volatile oil component, a plant metabolite, and a xenobiotic metabolite. It interacts with microbial cell membranes, disrupting their structure and function.
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|---|---|
| ln Vitro |
Cumic alcohol has antioxidant activity, anticancer activity, and cytotoxicity. It inhibits the formation of advanced glycation end-products. It has insecticidal effect. It is used as a stabilizer and preservative in various experimental applications.
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| ln Vivo |
Cumic alcohol is used as a natural product with insecticidal effect. It has antioxidant activity and anticancer activity. It is used as a stabilizer and preservative.
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| Enzyme Assay |
Cumic alcohol is evaluated in cell-free assays for its antioxidant activity using DPPH or ABTS radical scavenging assays. Its ability to inhibit the formation of advanced glycation end-products is assessed using biochemical assays.
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| Cell Assay |
No specific cell-based assays are documented for Cumic alcohol. It has been shown to have cytotoxic activity against cancer cell lines. Its antimicrobial activity can be assessed in bacterial culture assays.
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| Animal Protocol |
Cumic alcohol is administered in animal models to evaluate its insecticidal and antioxidant effects. However, specific animal study protocols are not extensively documented. It is a natural product.
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| ADME/Pharmacokinetics |
Cumic alcohol has a molecular weight of 150.22 and a molecular formula of C10H14O. It has a CAS number of 536-60-7. The compound is a liquid with a density of 0.98 g/cm3. It should be stored under recommended conditions.
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| Toxicity/Toxicokinetics |
No detailed toxicity data is available for Cumic alcohol. The compound is for research use only and is not intended for human therapeutic use. It is a natural product and is generally recognized as safe for use as a flavoring agent.
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| References | |
| Additional Infomation |
4-Isopropylbenzyl alcohol is a type of benzyl alcohol compound in which the hydrogen at the 4-position of the benzene ring is replaced by an isopropyl group. It can be used as a fragrance, insect repellent, volatile oil component, plant metabolite, and exogenous metabolite. It is a p-menthane monoterpene compound belonging to the benzyl alcohol class. Its function is similar to that of p-cymene. 4-Isopropylbenzyl alcohol has been reported to exist in Angelica sinensis, Rhodiola rosea, and other organisms with relevant data.
Cumic alcohol is also known as 4-isopropylbenzyl alcohol, cuminol, and p-cymen-7-ol. It is a p-menthane monoterpenoid. It has insecticidal effect. It is not approved for clinical use. |
| Molecular Formula |
C10H14O
|
|---|---|
| Molecular Weight |
150.22
|
| Exact Mass |
150.104
|
| CAS # |
536-60-7
|
| PubChem CID |
325
|
| Appearance |
Colorless to light yellow liquid
|
| Density |
1.0±0.1 g/cm3
|
| Boiling Point |
249.0±0.0 °C at 760 mmHg
|
| Melting Point |
28 °C
|
| Flash Point |
106.0±3.7 °C
|
| Vapour Pressure |
0.0±0.5 mmHg at 25°C
|
| Index of Refraction |
1.524
|
| LogP |
2.37
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
11
|
| Complexity |
101
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CC(C)C1=CC=C(C=C1)CO
|
| InChi Key |
OIGWAXDAPKFNCQ-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C10H14O/c1-8(2)10-5-3-9(7-11)4-6-10/h3-6,8,11H,7H2,1-2H3
|
| Chemical Name |
(4-propan-2-ylphenyl)methanol
|
| Synonyms |
NSC-15672; NSC 15672; Cumic alcohol
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~665.69 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (16.64 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (16.64 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (16.64 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.6569 mL | 33.2845 mL | 66.5690 mL | |
| 5 mM | 1.3314 mL | 6.6569 mL | 13.3138 mL | |
| 10 mM | 0.6657 mL | 3.3285 mL | 6.6569 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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