| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| Other Sizes |
| Targets |
Creatine D3 hydrate targets creatine kinase enzymes, which include the M-type, U-type (mitochondrial), and B-type. These enzymes play a crucial role in energy metabolism in tissues with high and fluctuating energy demands, such as skeletal muscle and the brain. As a deuterium-labeled compound, it is used as a tracer.
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|---|---|
| ln Vitro |
In vitro, Creatine D3 hydrate is used as a tracer in metabolic studies to track creatine metabolism. Creatine hydrate is essential for energy metabolism in muscle and brain cells. The deuterium label allows for precise quantification using mass spectrometry.
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| ln Vivo |
In vivo, Creatine D3 hydrate is used as a tracer to study creatine metabolism in vivo. Creatine hydrate is essential for energy metabolism in muscle and brain cells. The compound has potential therapeutic applications.
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| Enzyme Assay |
In vitro assays for Creatine D3 hydrate involve measuring its uptake and metabolism in cell cultures. Cells are incubated with the compound, and the levels of labeled creatine and its metabolites are measured using mass spectrometry.
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| Cell Assay |
Cellular assays for Creatine D3 hydrate are performed using muscle or brain cells. Cells are treated with the compound, and its incorporation into the cellular energy metabolism is assessed. The deuterium label allows for tracking of creatine metabolism.
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| Animal Protocol |
In vivo animal studies for Creatine D3 hydrate are not detailed in the available sources. The compound is used as a tracer in metabolic studies. Specific animal models and dosing regimens have not been described.
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| ADME/Pharmacokinetics |
Creatine D3 hydrate is a deuterium-labeled compound used as a tracer. It has a molecular weight of 152.17 g/mol. Specific PK parameters such as half-life, bioavailability, and clearance are not detailed in the available sources.
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| Toxicity/Toxicokinetics |
Toxicity data for Creatine D3 hydrate are not reported in the available sources. Creatine hydrate is generally considered safe. The deuterium-labeled form is expected to have a similar safety profile.
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| References | |
| Additional Infomation |
Creatine D3 hydrate is a deuterium-labeled form of creatine used as a tracer in metabolic studies. Creatine is pivotal in energy metabolism. The compound is available from commercial suppliers for research purposes.
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| Molecular Formula |
C4H9N3O2.H2O
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|---|---|
| Molecular Weight |
149.14844
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| Exact Mass |
152.098
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| CAS # |
284664-86-4
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| Related CAS # |
Creatine;57-00-1
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| PubChem CID |
16213871
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| Appearance |
White to off-white solid powder
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| Melting Point |
292ºC (dec.)(lit.)
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
10
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| Complexity |
134
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| Defined Atom Stereocenter Count |
0
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| SMILES |
[2H]C([2H])([2H])N(CC(=O)O)C(=N)N.O
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| InChi Key |
MEJYXFHCRXAUIL-NIIDSAIPSA-N
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| InChi Code |
InChI=1S/C4H9N3O2.H2O/c1-7(4(5)6)2-3(8)9;/h2H2,1H3,(H3,5,6)(H,8,9);1H2/i1D3;
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| Chemical Name |
2-[carbamimidoyl(trideuteriomethyl)amino]acetic acid;hydrate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~25 mg/mL (~164.29 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 6.67 mg/mL (43.83 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.7047 mL | 33.5233 mL | 67.0466 mL | |
| 5 mM | 1.3409 mL | 6.7047 mL | 13.4093 mL | |
| 10 mM | 0.6705 mL | 3.3523 mL | 6.7047 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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