| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| Other Sizes |
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| ln Vitro |
Cystrol suppresses vitality and tone and promotes the recruitment of ES2 (clear cell/serious carcinogen) cells by means of PI3K and ERK1/2 MAPK. Furthermore, immunoreactive PCNA expression and ERBB2 (a late cancer repair signature) were found in ES2 cell death triggered by cholesterol. Coumestrol administration inactivates the phosphorylation of AKT, p70S6K, ERK1/2, JNK1/2, and p90RSK in a time- and dose-regulated manner [1]. Neocuproline and ROS scavenger, a copper linker combination, prevents the apoptotic process that is triggered by caffeine's inhibition of MCF-7 cell proliferation. Treatment with cholesterol causes DNA fragmentation and ROS production, as well as p53 and p21 overexpression, G1/S phase cell cycle growth, deminimization of the midmembrane, and caspase 9/3 activation [2].
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| References | |
| Additional Infomation |
Coumestrol is a member of the class of coumestans that is coumestan with hydroxy substituents at positions 3 and 9. It has a role as an anti-inflammatory agent, an antioxidant and a plant metabolite. It is a member of coumestans, a delta-lactone and a polyphenol. It is functionally related to a coumestan.
Coumestrol has been reported in Glycine max, Campylotropis hirtella, and other organisms with data available. A daidzein derivative occurring naturally in forage crops which has some estrogenic activity. See also: Coumestan (subclass of); Medicago sativa whole (part of). |
| Molecular Formula |
C15H8O5
|
|---|---|
| Molecular Weight |
268.22
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| Exact Mass |
268.037
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| CAS # |
479-13-0
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| PubChem CID |
5281707
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| Appearance |
Light yellow to brown solid powder
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| Density |
1.6±0.1 g/cm3
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| Boiling Point |
406.0±24.0 °C at 760 mmHg
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| Melting Point |
≥350ºC(lit.)
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| Flash Point |
199.3±22.9 °C
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| Vapour Pressure |
0.0±1.0 mmHg at 25°C
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| Index of Refraction |
1.768
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| LogP |
2.94
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
20
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| Complexity |
411
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
ZZIALNLLNHEQPJ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C15H8O5/c16-7-1-3-9-11(5-7)19-14-10-4-2-8(17)6-12(10)20-15(18)13(9)14/h1-6,16-17H
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| Chemical Name |
3,9-dihydroxy-[1]benzofuro[3,2-c]chromen-6-one
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| Synonyms |
BRN0266702; BRN 0266702; Coumestrol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~25 mg/mL (~93.21 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (9.32 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7283 mL | 18.6414 mL | 37.2828 mL | |
| 5 mM | 0.7457 mL | 3.7283 mL | 7.4566 mL | |
| 10 mM | 0.3728 mL | 1.8641 mL | 3.7283 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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