| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| Other Sizes |
| Targets |
Cortisol sulfate sodium targets intracellular transcortin (also known as corticosteroid-binding globulin). As a metabolite of cortisol, it is involved in regulating inflammation, blood pressure, and glucose metabolism. It may also affect behavior through actions on the central nervous system.
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|---|---|
| ln Vitro |
As a metabolite, its primary in vitro activity is its ability to act as a specific ligand for intracellular transcortin. It is used as a reference compound in metabolomics studies to understand cortisol metabolism and its role in conditions like obesity, diabetes, and psychiatric disorders.
|
| ln Vivo |
By directly affecting the central nervous system, cortisol sulfate sodium (3 mg; IM; every other day; for 2–7 weeks) has an impact on behavior [4].
Dedicated in vivo studies have shown that Cortisol sulfate sodium (3 mg; intramuscular injection; every other day; for 2-7 weeks) affects behavior through its direct action on the central nervous system. It is also a proposed lung, breast, and liver cancer biomarker. |
| Enzyme Assay |
Cortisol sulfate sodium is primarily used as a reference standard. Binding assays to intracellular transcortin can be performed using radiolabeled competition assays. The metabolite is applied to cells or tissue homogenates, and its specific binding is measured.
|
| Cell Assay |
Cell-based studies are not typical for this metabolite. Instead, it is used as a standard in analytical chemistry. For biological studies, cells (e.g., neuronal cell lines) are treated with the compound, and markers related to stress response or glucocorticoid activity may be measured.
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| Animal Protocol |
In animal studies, cortisol sulfate sodium is administered via intramuscular injection in rodent models to study its effects on the central nervous system and behavior. Its levels in urine are measured as a biomarker in cancer and metabolic disease models.
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| ADME/Pharmacokinetics |
As an endogenous metabolite and research standard, detailed PK studies are not a focus. Cortisol sulfate is primarily renally excreted and serves as a biomarker. Its PK profile is similar to other sulfate-conjugated steroids.
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| Toxicity/Toxicokinetics |
As an endogenous compound and metabolite of cortisol, Cortisol sulfate sodium has a well-established safety profile at physiological levels. At research concentrations, standard laboratory safety precautions are sufficient. It is not a cytotoxic agent.
|
| References | |
| Additional Infomation |
Cortisol sulfate sodium is a research tool for studying steroid hormone metabolism. It is used as a urinary biomarker for various cancers. Its applications in metabolomics extend to studying stress response, adrenal function, and its links to metabolic disorders. It is not a therapeutic drug.
|
| Molecular Formula |
C21H30O8S.NA
|
|---|---|
| Molecular Weight |
464.50500
|
| Exact Mass |
464.148
|
| CAS # |
1852-36-4
|
| Related CAS # |
Cortisol sulfate;1253-43-6
|
| PubChem CID |
23674504
|
| Appearance |
White to off-white solid powder
|
| LogP |
2.346
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
8
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
31
|
| Complexity |
911
|
| Defined Atom Stereocenter Count |
7
|
| SMILES |
C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)COS(=O)(=O)[O-])O)C)O.[Na+]
|
| InChi Key |
DJKQHUMDQFOLHE-WDCKKOMHSA-M
|
| InChi Code |
InChI=1S/C21H30O8S.Na/c1-19-7-5-13(22)9-12(19)3-4-14-15-6-8-21(25,17(24)11-29-30(26,27)28)20(15,2)10-16(23)18(14)19;/h9,14-16,18,23,25H,3-8,10-11H2,1-2H3,(H,26,27,28);/q;+1/p-1/t14-,15-,16-,18+,19-,20-,21-;/m0./s1
|
| Chemical Name |
sodium;[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] sulfate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~215.29 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.38 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (5.38 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (5.38 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1528 mL | 10.7640 mL | 21.5281 mL | |
| 5 mM | 0.4306 mL | 2.1528 mL | 4.3056 mL | |
| 10 mM | 0.2153 mL | 1.0764 mL | 2.1528 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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