| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| Other Sizes |
| Targets |
Coniferyl ferulate targets oxidative stress pathways and inflammatory mediators. As a phenolic compound with a ferulic acid moiety, it may interact with free radicals and reactive oxygen species, exhibiting antioxidant activity. It may also modulate NF-κB and other inflammatory signaling pathways.
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|---|---|
| ln Vitro |
Coniferyl ferulate exhibits antioxidant activity through its phenolic hydroxyl groups, which can scavenge free radicals and chelate metal ions. It may also demonstrate anti-inflammatory effects by modulating cytokine production and inhibiting pro-inflammatory enzymes such as COX and LOX. Limited in vitro data are available.
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| ln Vivo |
In vivo activity of Coniferyl ferulate is not well documented. As a phenolic ester, it may be hydrolyzed in the gastrointestinal tract to release ferulic acid and coniferyl alcohol, which are absorbed and may exert systemic antioxidant and anti-inflammatory effects similar to other hydroxycinnamic acid derivatives.
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| Enzyme Assay |
In vitro enzyme assays for Coniferyl ferulate typically involve antioxidant activity measurements using DPPH, ABTS, or FRAP assays to quantify radical scavenging capacity. Enzyme inhibition assays for COX, LOX, or other inflammatory enzymes can be performed using colorimetric or fluorometric substrates to determine IC₅₀ values.
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| Cell Assay |
In vitro cell-based assays for Coniferyl ferulate use cell lines such as macrophages, endothelial cells, or cancer cells. Cells are treated with the compound and assessed for oxidative stress markers (ROS, MDA, GSH), inflammatory cytokine production (IL-6, TNF-α, IL-1β), and activation of signaling pathways (NF-κB, Nrf2) using ELISA, Western blot, or qPCR.
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| Animal Protocol |
In vivo animal studies for Coniferyl ferulate would typically involve oral administration to rodents followed by assessment of antioxidant status, inflammatory markers, and organ protection in models of oxidative stress or inflammation. However, specific studies for this compound are limited.
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| ADME/Pharmacokinetics |
Coniferyl ferulate has a molecular weight of approximately 356.37 g/mol and formula C₂₀H₂₀O₆. As a phenolic ester, it is expected to have moderate lipophilicity, allowing membrane permeability. It may be hydrolyzed to ferulic acid and coniferyl alcohol upon absorption. Detailed PK data are not available.
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| Toxicity/Toxicokinetics |
Coniferyl ferulate is considered to have low toxicity as a natural phenolic compound. No significant toxicity has been reported. Standard safety precautions for handling phenolic compounds should be followed.
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| References | |
| Additional Infomation |
Ferulic acid has been reported to be found in Coreopsis grandiflora, Ligusticum chuanxiong, and other organisms for which data are available. See also: Angelica sinensis root oil (partial).
Coniferyl ferulate is a naturally occurring phenolic ester found in plants such as monocotyledons and is studied for its potential antioxidant, anti-inflammatory, and chemopreventive properties. It is used as a research compound in natural product chemistry and phytochemical studies. Not approved for clinical use. |
| Molecular Formula |
C20H20O6
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|---|---|
| Molecular Weight |
356.3692
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| Exact Mass |
356.125
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| CAS # |
63644-62-2
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| PubChem CID |
6441913
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| Appearance |
Light yellow to yellow solid powder
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
570.5±50.0 °C at 760 mmHg
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| Flash Point |
202.8±23.6 °C
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| Vapour Pressure |
0.0±1.6 mmHg at 25°C
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| Index of Refraction |
1.640
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| LogP |
2.78
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
8
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| Heavy Atom Count |
26
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| Complexity |
489
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| Defined Atom Stereocenter Count |
0
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| SMILES |
COC1=C(C=CC(=C1)/C=C/COC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O
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| InChi Key |
PGLIMMMHQDNVRS-YZQQHVNFSA-N
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| InChi Code |
InChI=1S/C20H20O6/c1-24-18-12-14(5-8-16(18)21)4-3-11-26-20(23)10-7-15-6-9-17(22)19(13-15)25-2/h3-10,12-13,21-22H,11H2,1-2H3/b4-3+,10-7+
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| Chemical Name |
[(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enyl] (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~280.61 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (7.02 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.02 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8061 mL | 14.0304 mL | 28.0607 mL | |
| 5 mM | 0.5612 mL | 2.8061 mL | 5.6121 mL | |
| 10 mM | 0.2806 mL | 1.4030 mL | 2.8061 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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