| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 10mg |
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| 50mg |
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| Other Sizes |
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| ln Vitro |
When it comes to iron(III), CN128 hydrochloride is more selective than other metals [1].
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|---|---|
| ln Vivo |
Rats that are given CN128 hydrochloride (450 μmol/kg; po) show good iron scavenging efficacy [1]. There is a dose-dependent pattern to CN128's iron-removing effectiveness [1]. It is not genotoxic to use CN128 hydrochloride [1]. After oral administration of 75 μmol/kg in rats, CN128 hydrochloride (ig) has a low clearance rate, a high maximum plasma concentration, and good oral bioavailability (82.6%) [1]. Rats showed good tolerance to CN128 hydrochloride, and no fatalities were reported at increased dosage levels [1].
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| Animal Protocol |
Animal/Disease Models: Male SD rat (300 g) [1]
Doses: 450 μmol/kg Route of Administration: po (oral gavage) 1 hour after injection of 59Fe-ferritin. Experimental Results: It demonstrated good iron scavenging activity. Animal/Disease Models: SD (SD (Sprague-Dawley)) rat (200~250 g) [1] Doses: 75 μmol/kg (pharmacokinetic/PK/PK analysis) Route of Administration: Oral administration Experimental Results: AUC value = 16.38 mg/L·h, Cmax = 8.671 mg/L. |
| References |
| Molecular Formula |
C15H18CLNO3
|
|---|---|
| Molecular Weight |
295.761323451996
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| Exact Mass |
295.097
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| CAS # |
1335282-05-7
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| PubChem CID |
89953504
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| Appearance |
Off-white to light brown solid powder
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
20
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| Complexity |
394
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| Defined Atom Stereocenter Count |
1
|
| SMILES |
Cl.OC[C@@H](CC1C=CC=CC=1)N1C=CC(C(=C1C)O)=O
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| InChi Key |
CYFDKXLBMMEWNV-BTQNPOSSSA-N
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| InChi Code |
InChI=1S/C15H17NO3.ClH/c1-11-15(19)14(18)7-8-16(11)13(10-17)9-12-5-3-2-4-6-12;/h2-8,13,17,19H,9-10H2,1H3;1H/t13-;/m1./s1
|
| Chemical Name |
3-hydroxy-1-[(2R)-1-hydroxy-3-phenylpropan-2-yl]-2-methylpyridin-4-one;hydrochloride
|
| Synonyms |
CN 128; CN-128
|
| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~100 mg/mL (~338.11 mM)
DMSO : ~28.57 mg/mL (~96.60 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.86 mg/mL (9.67 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 28.6 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.86 mg/mL (9.67 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 28.6 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.86 mg/mL (9.67 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3811 mL | 16.9056 mL | 33.8112 mL | |
| 5 mM | 0.6762 mL | 3.3811 mL | 6.7622 mL | |
| 10 mM | 0.3381 mL | 1.6906 mL | 3.3811 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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