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    Clomifene citrate (Clomiphene)
    Clomifene citrate (Clomiphene)

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    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V1740
    CAS #: 50-41-9Purity ≥98%

    Description: Clomifene Citrate (NSC35770; NSC-35770; Omifin; Chloramiphene; Clomide; Clostilbegit; Clomid; Androxal; Dyneric; Gravosan; Klostilbegit; Serophene), the citrate salt of Clomifene, is a potent SERM (selective estrogen receptor modulator) that has been used in the treatment of ovulation induction. It acts by inhibiting the action of estrogen on the pituitary. 

    References: Cancer Chemother Pharmacol. 1990;26(4):310-2; Dongwuxue Yanjiu. 2013 Oct;34(5):487-92.

    Related CAS #: 911-45-5 (free base)   50-41-9 (citrate)     

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    Molecular Weight (MW)598.08 
    FormulaC26H28ClNO.C6H8O7 
    CAS No.50-41-9 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 120 mg/mL (200.6 mM) 
    Water: <1 mg/mL
    Ethanol: 11 mg/mL (18.4 mM) 
    Solubility (In vivo)

    Chemical Name: 2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethylethanamine

    InChi Key: GKIRPKYJQBWNGO-QPLCGJKRSA-N

    InChi Code: InChI=1S/C26H28ClNO/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23/h5-18H,3-4,19-20H2,1-2H3/b26-25-

    SMILES Code: CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3           

    SynonymsNSC-35770; Clomiphene; D; Chloramiphene; NSC35770; NSC 35770; Omifin; Citrate; Clomiphene; Clomide; Clomifen; Clostilbegit; Clomid; Androxal; Dyneric; Gravosan; Klostilbegit; Serophene


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    In Vitro

    In vitro activity: Clomifene competes with [3H]-QNB and [3H]-nitrendipine for their binding to the receptor in the membrane fractions from the urinary bladder and myometrium. Clomifene inhibits estrogen receptors in the hypothalamus, inhibiting negative feedback of estrogen on gonadotropinrelease, leading to up-regulation of the hypothalamic–pituitary–gonadal axis. Clomifene is a mixture of two geometric isomers, enclomifene (E-clomifene) and zuclomifene (Z-clomifene). 

    In VivoClomiphene citrate treatment significantly increases the chance of homosexuality and effeminized behavior in male mice.
    Animal modelMice
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    References

    Cancer Chemother Pharmacol. 1990;26(4):310-2; Dongwuxue Yanjiu. 2013 Oct;34(5):487-92. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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