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Description: Clomifene Citrate (NSC35770; NSC-35770; Omifin; Chloramiphene; Clomide; Clostilbegit; Clomid; Androxal; Dyneric; Gravosan; Klostilbegit; Serophene), the citrate salt of Clomifene, is a potent SERM (selective estrogen receptor modulator) that has been used in the treatment of ovulation induction. It acts by inhibiting the action of estrogen on the pituitary.
References: Cancer Chemother Pharmacol. 1990;26(4):310-2; Dongwuxue Yanjiu. 2013 Oct;34(5):487-92.
Related CAS #: 911-45-5 (free base) 50-41-9 (citrate)
Product Catalog 2022
Guide to Product Handling
Chemical Name: 2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethylethanamine
InChi Key: GKIRPKYJQBWNGO-QPLCGJKRSA-N
InChi Code: InChI=1S/C26H28ClNO/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23/h5-18H,3-4,19-20H2,1-2H3/b26-25-
SMILES Code: CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
In vitro activity: Clomifene competes with [3H]-QNB and [3H]-nitrendipine for their binding to the receptor in the membrane fractions from the urinary bladder and myometrium. Clomifene inhibits estrogen receptors in the hypothalamus, inhibiting negative feedback of estrogen on gonadotropinrelease, leading to up-regulation of the hypothalamic–pituitary–gonadal axis. Clomifene is a mixture of two geometric isomers, enclomifene (E-clomifene) and zuclomifene (Z-clomifene).
Cancer Chemother Pharmacol. 1990;26(4):310-2; Dongwuxue Yanjiu. 2013 Oct;34(5):487-92.
Purity ≥98%
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