| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 50mg |
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CL-316243 disodium (CL316243) is a novel and potent β3-adrenoceptor agonist with the potential for the treatment obesity, diabetes and urge urinary incontinence. It activates β3-adrenoceptor with a EC50 of 3 nM.
| Targets |
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|---|---|---|
| ln Vitro |
Clenidine 316243 has IC50 values of 0.6 μM and 1 μM, respectively, against the rat heart and soleus muscle[1]. Based on concentration-dependent inhibition, CL 316243 prevents 50% of the maximal response from spontaneous contractions in isolated rat detrusor muscle strips at an average dose of 2.65 nM [3].
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| ln Vivo |
Unaffected by food, CL316243 disodium (subcutaneous injection; 0.1 mg/kg/d; once daily; 1 week) raises BAT's levels of UCP1 mRNA and protein expression [2].
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| Animal Protocol |
Animal/Disease Models: Male C57BL/6J mice fed with high-fat diets (HFD; 45%-kcal fat) or a control diet (ND; 10%-kcal fat) for 14 weeks[2]
Doses: 0.1 mg/kg/day Route of Administration: one time/day; 1 weeks Experimental Results: demonstrated a premium effect of obesity in mice. |
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| References |
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| Molecular Formula |
C20H18CLNNA2O7
|
|---|---|
| Molecular Weight |
465.7935
|
| Exact Mass |
465.057
|
| CAS # |
138908-40-4
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| PubChem CID |
5312115
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| Appearance |
White to yellow solid powder
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| Boiling Point |
689.5ºC at 760 mmHg
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| Flash Point |
370.8ºC
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| Vapour Pressure |
5.86E-20mmHg at 25°C
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| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
8
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
31
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| Complexity |
578
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| Defined Atom Stereocenter Count |
2
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| SMILES |
C[C@H](CC1=CC2=C(C=C1)OC(O2)(C(=O)[O-])C(=O)[O-])NC[C@@H](C3=CC(=CC=C3)Cl)O.[Na+].[Na+]
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| InChi Key |
FUZBPOHHSBDTJQ-CFOQQKEYSA-L
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| InChi Code |
InChI=1S/C20H20ClNO7.2Na/c1-11(22-10-15(23)13-3-2-4-14(21)9-13)7-12-5-6-16-17(8-12)29-20(28-16,18(24)25)19(26)27;;/h2-6,8-9,11,15,22-23H,7,10H2,1H3,(H,24,25)(H,26,27);;/q;2*+1/p-2/t11-,15+;;/m1../s1
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| Chemical Name |
disodium;5-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate
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| Synonyms |
CL316243 CL 316243 CL-316243
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~20 mg/mL (~42.94 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (214.69 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1469 mL | 10.7345 mL | 21.4689 mL | |
| 5 mM | 0.4294 mL | 2.1469 mL | 4.2938 mL | |
| 10 mM | 0.2147 mL | 1.0734 mL | 2.1469 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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