| Size | Price | Stock | Qty |
|---|---|---|---|
| 250mg |
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| 500mg |
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| 1g |
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| Other Sizes |
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Purity: =98.26%
| Targets |
Natural coumarin
|
|---|---|
| ln Vitro |
Citropten (5,7-dimethoxycoumarin) combined with valproic acid (4 mM) significantly reduced viability of A2058 human melanoma cells after 48-hour exposure (p < 0.001). Neither compound alone affected cell viability at tested concentrations [2]
|
| Cell Assay |
Human skin penetration study: 6 volunteers applied 20 mg/cm² of a cream containing 0.5% citropten on solar simulator-irradiated forearm skin. Suction blisters were generated 8 hours post-application. Blister fluid was collected, mixed with methanol, centrifuged, and analyzed by HPLC [1]
|
| Animal Protocol |
Human skin penetration study: 6 volunteers applied 20 mg/cm² of a cream containing 0.5% citropten on solar simulator-irradiated forearm skin. Suction blisters were generated 8 hours post-application. Blister fluid was collected, mixed with methanol, centrifuged, and analyzed by HPLC [1]
|
| ADME/Pharmacokinetics |
Dermal penetration: HPLC analysis detected citropten in human blister fluid at 0.40% ± 0.04% of the applied dose 8 hours after topical administration [1]
Skin clearance: No citropten was detected in blister fluid 24 hours after cream removal [1] |
| References |
|
| Additional Infomation |
Citropten is a coumarin derivative naturally occurring in citrus plants [1]
Synergistic antiproliferative effect observed when citropten was combined with valproic acid against melanoma cells [2] 5,7-dimethoxy-1-benzopyran-2-one is a member of coumarins. 5,7-Dimethoxycoumarin has been reported in Edgeworthia chrysantha, Citrus medica, and other organisms with data available. |
| Molecular Formula |
C11H10O4
|
|---|---|
| Molecular Weight |
206.1947
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| Exact Mass |
206.057
|
| Elemental Analysis |
C, 64.08; H, 4.89; O, 31.04
|
| CAS # |
487-06-9
|
| PubChem CID |
2775
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| Appearance |
White to light yellow solid powder
|
| Density |
1.2±0.1 g/cm3
|
| Boiling Point |
388.1±42.0 °C at 760 mmHg
|
| Melting Point |
146-149 °C(lit.)
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| Flash Point |
176.3±27.9 °C
|
| Vapour Pressure |
0.0±0.9 mmHg at 25°C
|
| Index of Refraction |
1.557
|
| LogP |
2.06
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
15
|
| Complexity |
274
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
COC1=CC2=C(C=CC(=O)O2)C(=C1)OC
|
| InChi Key |
NXJCRELRQHZBQA-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C11H10O4/c1-13-7-5-9(14-2)8-3-4-11(12)15-10(8)6-7/h3-6H,1-2H3
|
| Chemical Name |
5,7-dimethoxychromen-2-one
|
| Synonyms |
citropten; 5,7-Dimethoxycoumarin; NSC102793; 487-06-9; Limettin; 5,7-dimethoxychromen-2-one; JWE1QQ247N; NSC-102793; 207-646-4; .
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~25 mg/mL (~121.24 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (10.09 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (10.09 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.8499 mL | 24.2495 mL | 48.4990 mL | |
| 5 mM | 0.9700 mL | 4.8499 mL | 9.6998 mL | |
| 10 mM | 0.4850 mL | 2.4249 mL | 4.8499 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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