| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
|
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| 5g |
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| Other Sizes |
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
Cinnamyl alcohol is absorbed through the skin at a rate of 66% and has been shown to be rapidly absorbed by the intestines. It is primarily metabolized and excreted in the urine, with a small amount excreted in the feces. Following oral or intraperitoneal injection of cinnamyl alcohol in rats and mice, 76-77% of the dose was recovered in urine and feces within 24 hours. Following administration of a neutral extract to rats, cinnamyl alcohol was excreted unchanged. Metabolism/Metabolites Typically, esters containing aromatic ring systems are expected to hydrolyze in vivo. Cinnamyl alcohol is hydrolyzed to form [DB14184]. Acidic and neutral urinary metabolites of cinnamyl alcohol were identified via a common metabolic pathway. Cinnamyl alcohol is a known human metabolite of β-methylstyrene. |
|---|---|
| References | |
| Additional Infomation |
Cinnamyl alcohol is a primary alcohol with an allyl core, a hydroxyl substituent at the 1-position, and a phenyl substituent at the 3-position (the geometry of the C=C bond is not defined). It is a plant metabolite. Cinnamyl alcohol is a natural compound found in cinnamon. Due to its low abundance in cinnamon, it is commonly found in commercial products as [DB14184]. Studies have shown that cinnamyl alcohol is a skin sensitizer with a no-effect concentration (NOEL) of approximately 4%. Sensitivity to cinnamyl alcohol can be identified through clinical patch testing. Cinnamyl alcohol is a standardized chemical allergen. The physiological effects of cinnamyl alcohol are achieved through increased histamine release and cell-mediated immunity. Cinnamyl alcohol has been reported in Rhodiola rosea, Sophora flavescens, and other organisms with relevant data. See also: Cinnamon (partial); Chinese cinnamon (partial); Cinnamon twig (partial).
Drug Indications Cinnamyl alcohol has been approved by the U.S. Food and Drug Administration (FDA) for use in allergic skin patch testing, which is indicated for the auxiliary diagnosis of allergic contact dermatitis (ACD) in individuals aged 6 years and older. |
| Molecular Formula |
C9H10O
|
|---|---|
| Molecular Weight |
134.1751
|
| Exact Mass |
134.073
|
| CAS # |
104-54-1
|
| PubChem CID |
5315892
|
| Appearance |
White to light yellow <30°C powder,>33°C liquid
|
| Density |
1.0±0.1 g/cm3
|
| Boiling Point |
250.0±0.0 °C at 760 mmHg
|
| Melting Point |
30-33 °C(lit.)
|
| Flash Point |
124.8±14.5 °C
|
| Vapour Pressure |
0.0±0.5 mmHg at 25°C
|
| Index of Refraction |
1.599
|
| LogP |
1.7
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
10
|
| Complexity |
101
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
C1=CC=C(C=C1)/C=C/CO
|
| InChi Key |
OOCCDEMITAIZTP-QPJJXVBHSA-N
|
| InChi Code |
InChI=1S/C9H10O/c10-8-4-7-9-5-2-1-3-6-9/h1-7,10H,8H2/b7-4+
|
| Chemical Name |
(E)-3-phenylprop-2-en-1-ol
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~250 mg/mL (~1863.17 mM)
H2O : ~100 mg/mL (~745.27 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 6.25 mg/mL (46.58 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 62.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 6.25 mg/mL (46.58 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 62.5 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 6.25 mg/mL (46.58 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.4527 mL | 37.2634 mL | 74.5268 mL | |
| 5 mM | 1.4905 mL | 7.4527 mL | 14.9054 mL | |
| 10 mM | 0.7453 mL | 3.7263 mL | 7.4527 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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