| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
Cetyl bromide functions as a competitive antagonist of muscarinic-mediated contractions in isolated colonic preparations of both species, with affinity values (pA2) varying from 7.41 to 7.82 [1]. The contraction of longitudinal muscle preparations is inhibited by ceytropium bromide's strong antimuscarinic properties. Cimetropium bromide decreased the release of labeled acetylcholine generated by electric field stimulation in perfusion tests using preloaded labeled choline preparations under muscarinic autoinhibitory blockade conditions [2].
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| ln Vivo |
Cetyl bromide is an effective intravenous medication that inhibits both endogenous and external stimuli-induced large intestinal motility in awake dogs with colic-Tirri fistulas. The colonic motor response to neostigmine treatment is counteracted by cetyl bromide (10-100 μg/kg), with an ID50 of 27.9 μg/kg; this affects both the tonic and phasic components of the contractile response. The medication suppresses intraluminal dilatation-induced locomotor activity within a similar dosing range (3-100 μg/kg) [1].
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| References |
| Molecular Formula |
C21H28BRNO3
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|---|---|
| Molecular Weight |
422.36
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| Exact Mass |
437.12
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| CAS # |
51598-60-8
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| PubChem CID |
20054870
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| Appearance |
White to off-white solid powder
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
7
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| Heavy Atom Count |
27
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| Complexity |
538
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| Defined Atom Stereocenter Count |
5
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| SMILES |
C[N+]1([C@@H]2CC(C[C@H]1[C@H]3[C@@H]2O3)OC(=O)[C@H](CO)C4=CC=CC=C4)CC5CC5.[Br-]
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| InChi Key |
WDURTRGFUGAJHA-HNHWXVNLSA-M
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| InChi Code |
InChI=1S/C21H28NO4.BrH/c1-22(11-13-7-8-13)17-9-15(10-18(22)20-19(17)26-20)25-21(24)16(12-23)14-5-3-2-4-6-14;/h2-6,13,15-20,23H,7-12H2,1H3;1H/q+1;/p-1/t15?,16-,17-,18+,19-,20+,22?;/m1./s1
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| Chemical Name |
[(1R,2R,4S,5S)-9-(cyclopropylmethyl)-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonan-7-yl] (2S)-3-hydroxy-2-phenylpropanoate;bromide
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| Synonyms |
Cimetropii bromidum; Alginor; Cimetropium bromide
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~50 mg/mL (~114.06 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (228.12 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3676 mL | 11.8382 mL | 23.6765 mL | |
| 5 mM | 0.4735 mL | 2.3676 mL | 4.7353 mL | |
| 10 mM | 0.2368 mL | 1.1838 mL | 2.3676 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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