| Size | Price | Stock | Qty |
|---|---|---|---|
| 1g |
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| Other Sizes |
| Targets |
As a synthetic dye, C.I. Acid Red 18 does not have a specific pharmacological target. Its primary applications are as a food colorant and industrial dye. The compound may interact with biological systems through non-specific mechanisms. It has been shown to be effective in the treatment of wastewater and infectious diseases, such as cholera and typhoid fever.
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|---|---|
| ln Vitro |
C.I. Acid Red 18 itself is not known to possess direct therapeutic activity. Its significance is as a synthetic dye for food, textile, and industrial applications. The compound is used as a colorant in foods, beverages, and pharmaceuticals. As an azo dye, it may undergo metabolic reduction to aromatic amines, which could have biological effects.
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| ln Vivo |
There is no reported in vivo therapeutic activity for C.I. Acid Red 18 as a drug candidate. The compound is primarily used as a food colorant and industrial dye. It has been used in the treatment of wastewater. Its role in biological systems is primarily as a coloring agent rather than a pharmacologically active compound.
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| Enzyme Assay |
As a synthetic dye, there are no standardized in vitro enzyme/receptor binding assays for C.I. Acid Red 18 itself. The compound's utility is in food, textile, and industrial applications. Researchers may study the compound's interactions with biological systems in the context of dye metabolism, toxicity, or analytical method development.
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| Cell Assay |
There are no reported in vitro cellular assays for C.I. Acid Red 18 as a therapeutic agent. The compound is used as a food colorant and industrial dye. Cellular studies may be conducted to assess the compound's toxicity, metabolism, or potential for causing allergic symptoms at high concentrations, but these are not therapeutic assays.
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| Animal Protocol |
There are no reported in vivo animal studies for C.I. Acid Red 18 as a therapeutic agent. The compound is primarily used as a food colorant and industrial dye. Animal studies may be conducted to assess the compound's toxicity, metabolism, or potential for causing allergic symptoms, but these are not therapeutic studies.
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| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
Intravenous injection of 50-100 μmol of neothecobalaine into rats with ligated renal pedicles resulted in a significant peak in bile excretion, which could be inhibited by phenolphthalein glucuronide or probenecid (both 50 μmol). Bile excretion may involve active transport processes. As a synthetic dye used in food and industrial applications, there are limited pharmacokinetic data for C.I. Acid Red 18. The compound has a molecular weight of 604.46 and is soluble in water, slightly soluble in ethanol, and insoluble in oils. It has a lambda max of 506.0 to 510.0 nm. The compound is stable to citric acid and tartaric acid. |
| Toxicity/Toxicokinetics |
Interactions
Adding 5% of Red 102 (New Red Scale, NC) to a basic purified low-fiber diet (25% casein-sucrose) resulted in severe growth retardation. Conversely, the addition of dietary fiber (GDF) from burdock (the root of edible burdock, scientifically known as Arctium Lappa L.) completely prevented the toxicity of the New Red Scale. C.I. Acid Red 18 is a long-term toxicant and can induce allergic symptoms at high concentrations. The compound has poor heat stability and reducing stability. In alkaline solutions, it turns brown. The compound should be handled with appropriate safety precautions. Toxicological studies would be needed to fully characterize its safety profile for any therapeutic applications. |
| References | |
| Additional Infomation |
C.I. Acid Red 18 (New Coccine, Ponceau 4R) is a synthetic azo dye used as a food colorant, textile dye, and in various industrial applications. It is a dark red powder with a molecular weight of 604.46. The compound is soluble in water, slightly soluble in ethanol, and insoluble in oils. It is a long-term toxicant that can induce allergic symptoms at high concentrations and is not a therapeutic agent.
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| Molecular Formula |
C20H11N2NA3O10S3
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|---|---|
| Molecular Weight |
604.4731
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| Exact Mass |
603.926
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| CAS # |
2611-82-7
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| PubChem CID |
17466
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| Appearance |
Brown to red solid powder
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| LogP |
6.068
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
12
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
38
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| Complexity |
1080
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
SWGJCIMEBVHMTA-UHFFFAOYSA-K
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| InChi Code |
InChI=1S/C20H14N2O10S3.3Na/c23-16-7-5-11-9-12(33(24,25)26)10-18(35(30,31)32)19(11)20(16)22-21-15-6-8-17(34(27,28)29)14-4-2-1-3-13(14)15;;;/h1-10,23H,(H,24,25,26)(H,27,28,29)(H,30,31,32);;;/q;3*+1/p-3
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| Chemical Name |
trisodium;7-hydroxy-8-[(4-sulfonatonaphthalen-1-yl)diazenyl]naphthalene-1,3-disulfonate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~25 mg/mL (~41.36 mM)
DMSO : ~10 mg/mL (~16.54 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1 mg/mL (1.65 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 10.0 mg/mL clear DMSO stock solution to 400 μL of PEG300 and mix evenly; then add 50 μL of Tween-80 to the above solution and mix evenly; then add 450 μL of normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1 mg/mL (1.65 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 10.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: 50 mg/mL (82.72 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.6543 mL | 8.2717 mL | 16.5434 mL | |
| 5 mM | 0.3309 mL | 1.6543 mL | 3.3087 mL | |
| 10 mM | 0.1654 mL | 0.8272 mL | 1.6543 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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