| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| Other Sizes |
| Targets |
As a histological stain, C.I. 74240 does not have a specific pharmacological target. It is a copper-containing phthalocyanine dye that binds to acid mucopolysaccharides and glycosaminoglycans through ionic interactions. The compound is used for staining bacteria, tissue cells, and fibroblasts in vivo and as a gelling agent for lubricants.
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|---|---|
| ln Vitro |
C.I. 74240 itself is not known to possess direct therapeutic activity. Its significance is as a histological stain for detecting acid mucopolysaccharides and glycosaminoglycans. The compound is used for staining bacteria, tissue cells, and fibroblasts in vivo and as a gelling agent for lubricants. There is no known therapeutic activity.
|
| ln Vivo |
There is no reported in vivo therapeutic activity for C.I. 74240. The compound is primarily used as a histological stain for acid mucopolysaccharides and glycosaminoglycans. It is used in vivo for staining bacteria, tissue cells, and fibroblasts. Its role in biological systems is as a staining agent rather than a pharmacologically active compound.
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| Enzyme Assay |
As a histological stain, there are no standardized in vitro enzyme/receptor binding assays for C.I. 74240. The compound's utility is in staining acid mucopolysaccharides and glycosaminoglycans. Researchers may study the compound's staining properties and binding to tissue components in the context of histology and microscopy.
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| Cell Assay |
There are no reported in vitro cellular assays for C.I. 74240 as a therapeutic agent. The compound is used as a histological stain. Cellular studies may be conducted to assess the compound's staining properties, toxicity, or binding to cellular components, but these are not therapeutic assays.
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| Animal Protocol |
There are no reported in vivo animal studies for C.I. 74240 as a therapeutic agent. The compound is primarily used as a histological stain for acid mucopolysaccharides and glycosaminoglycans. It is used in vivo for staining bacteria, tissue cells, and fibroblasts. Animal studies may be conducted to assess the compound's staining properties or toxicity.
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| ADME/Pharmacokinetics |
As a histological stain, there are limited pharmacokinetic data for C.I. 74240. The compound has a molecular weight of 1298.86 and a molecular formula of C56H68Cl4CuN16S4. It is a copper-containing phthalocyanine dye. The compound's distribution and metabolism have not been fully characterized.
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| Toxicity/Toxicokinetics |
C.I. 74240 should be handled with appropriate safety precautions. As a copper-containing compound, it may have toxicity concerns. The compound is used as a histological stain and gelling agent. Toxicological studies would be needed to fully characterize its safety profile for any potential applications.
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| References | |
| Additional Infomation |
C.I. 74240 (Alcian Blue 8GX, Ingrain Blue 1) is a copper-containing phthalocyanine dye used as a cationic stain for acid mucopolysaccharides and glycosaminoglycans, producing blue to bluish-green stained areas. It has a molecular formula of C56H68Cl4CuN16S4 and a molecular weight of 1298.86. The compound is used in vivo for staining bacteria, tissue cells, and fibroblasts and as a gelling agent for lubricants.
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| Molecular Formula |
C56H70CL4CUN16S4
|
|---|---|
| Molecular Weight |
1300.87
|
| Exact Mass |
721.167
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| CAS # |
33864-99-2
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| PubChem CID |
17749099
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| Appearance |
Dark purple to black solid powder
|
| Melting Point |
148ºC
|
| LogP |
3.447
|
| Hydrogen Bond Acceptor Count |
16
|
| Rotatable Bond Count |
16
|
| Heavy Atom Count |
81
|
| Complexity |
1750
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CN(C)C(=[N+](C)C)SCC1=CC2=C(C=C1)C3=NC4=C5C=C(C=CC5=C([N-]4)N=C6C7=C(C=CC(=C7)CSC(=[N+](C)C)N(C)C)C(=N6)N=C8C9=C(C=CC(=C9)CSC(=[N+](C)C)N(C)C)C(=N8)N=C2[N-]3)CSC(=[N+](C)C)N(C)C.[Cl-].[Cl-].[Cl-].[Cl-].[Cu+2]
|
| Synonyms |
NSC-324570; NSC 324570; C.I. 74240
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~125 mg/mL (~96.24 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (1.60 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.7687 mL | 3.8436 mL | 7.6872 mL | |
| 5 mM | 0.1537 mL | 0.7687 mL | 1.5374 mL | |
| 10 mM | 0.0769 mL | 0.3844 mL | 0.7687 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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