| Size | Price | Stock | Qty |
|---|---|---|---|
| 250mg |
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| 500mg |
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| Other Sizes |
| Targets |
Chlorindanol acts as a topical antimicrobial agent, though its precise molecular target is not fully elucidated. As an antiseptic, it likely disrupts microbial cell membranes and interferes with essential cellular processes. It exhibits rapid, broad-spectrum in vitro lethal activity against microorganisms and spermatozoa at low concentrations.
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|---|---|
| ln Vitro |
In vitro, chlorindanol demonstrates rapid, broad-spectrum antimicrobial activity against vegetative bacteria, Trichophyton spp., C. albicans, E. histolytica cysts and trophozoites, and T. vaginalis. It is rapidly lethal at low concentrations, making it effective as a topical disinfectant and spermicide. Specific MIC values are not extensively documented.
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| ln Vivo |
In vivo, chlorindanol is used as a topical antiseptic and spermicide. Its antimicrobial activity has been evaluated in topical applications for treating superficial skin conditions and as a contraceptive agent. Specific animal model data for in vivo efficacy are limited in the available literature.
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| Enzyme Assay |
Chlorindanol antimicrobial activity is determined by inoculating representative species of bacteria and fungi into liquid culture media containing varied concentrations of the compound. After incubation, microbial growth is assessed by turbidity or colony counting. MIC and MBC values are determined from dose-response curves.
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| Cell Assay |
In vitro antimicrobial assays are performed by inoculating microbial cultures (e.g., S. aureus, E. coli, C. albicans) into liquid media containing chlorindanol at various concentrations. Cultures are incubated at appropriate temperatures (35-37°C) for 18-24 h. Growth is assessed spectrophotometrically, and MIC values are determined. Spermicidal activity is assessed using sperm motility assays.
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| Animal Protocol |
In vivo efficacy as a topical antiseptic is evaluated in animal models of skin infection or wound contamination. Chlorindanol is applied topically as a cream or solution. Endpoints include reduction in microbial load, prevention of infection, and wound healing. Spermicidal efficacy is evaluated in animal models or in vitro assays.
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| ADME/Pharmacokinetics |
As a topical agent, chlorindanol has minimal systemic absorption. Pharmacokinetic parameters are primarily relevant to topical application, with local concentrations at the site of application being the key determinant of efficacy. Systemic exposure is expected to be low due to limited percutaneous absorption.
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| Toxicity/Toxicokinetics |
Chlorindanol is generally well-tolerated as a topical antiseptic. Local skin irritation or allergic reactions may occur in sensitive individuals. Systemic toxicity is rare due to minimal absorption. High concentrations may cause skin irritation. Safety in pregnancy has not been extensively studied.
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| Additional Infomation |
Therapeutic Uses
Chlorindanol combined with lauryl ether-9, in vitro studies have shown that it can render male sperm inactive within 20 seconds. 4-Chloro-7-hydroxyindanol at dilutions of 1:2000 and 1:4000 can kill Trichomonas vaginalis within 5 minutes. Chlorindanol can be considered a disinfectant. Spermicidal Agent Chlorindanol (7-Chloro-4-indanol) is a topical antiseptic and spermicidal agent. It has been used in topical formulations for skin disinfection and as a spermicidal agent in contraceptives. Its rapid, broad-spectrum antimicrobial and spermicidal activities make it useful for both antiseptic and contraceptive applications. |
| Molecular Formula |
C9H9CLO
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|---|---|
| Molecular Weight |
168.62
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| Exact Mass |
168.034
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| CAS # |
145-94-8
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| PubChem CID |
8961
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| Appearance |
NEEDLES FROM PETROLEUM ETHER
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| Density |
1.308g/cm3
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| Boiling Point |
290ºC at 760mmHg
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| Melting Point |
91-93ºC
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| Flash Point |
129.2ºC
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| Vapour Pressure |
0.00122mmHg at 25°C
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| Index of Refraction |
1.618
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| LogP |
2.534
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
11
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| Complexity |
149
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| Defined Atom Stereocenter Count |
0
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| SMILES |
ClC1C([H])=C([H])C(=C2C=1C([H])([H])C([H])([H])C2([H])[H])O[H]
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| InChi Key |
ATAJVFBUUIBIEO-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C9H9ClO/c10-8-4-5-9(11)7-3-1-2-6(7)8/h4-5,11H,1-3H2
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| Chemical Name |
7-chloro-2,3-dihydro-1H-inden-4-ol
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| Synonyms |
Lanesta; Chlorindanol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~593.05 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (14.83 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (14.83 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.9305 mL | 29.6525 mL | 59.3049 mL | |
| 5 mM | 1.1861 mL | 5.9305 mL | 11.8610 mL | |
| 10 mM | 0.5930 mL | 2.9652 mL | 5.9305 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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