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| 500mg |
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Chlorcyclizine HCl is an antihistamine drug of the phenylpiperazine class used primarily to treat allergy symptoms such as rhinitis, urticaria, and pruritus. It may also be used as an antiemetic. In addition to its antihistamine effects, chlorcyclizine also has anticholinergic, antiserotonergic, and local anesthetic properties.
| ln Vivo |
Rats in pregnancy that were given chlorcyclizine at doses of 30, 60, and 90 mg/kg at the delicate stage of palate development lived until their planned sacrifice on gestation day (GD) 17 or 21. Rats given 60 or 90 mg/kg of chlorcyclizine experienced 7% and 7% body weight loss, respectively, between doses, as well as temporary unfavorable clinical symptoms (rhinorrhea, red perioral material, urogenital staining, and loose stools). 11%. Rats given 30 mg/kg of chlorcyclizine during gestation did not acquire weight at the anticipated dose intervals, but they did not exhibit any negative clinical symptoms. Testing facility-based historical control database (16 studies, n = 380). Rats that are pregnant usually gain between 12 and 15 weeks of body weight [1].
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| References | |
| Additional Infomation |
Chlorcyclizine Hydrochloride can cause developmental toxicity according to state or federal government labeling requirements.
A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat ASTHMA; HAY FEVER; URTICARIA; and RHINITIS; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. See also: Chlorcyclizine (has active moiety) ... View More ... |
| Molecular Formula |
C18H21N2CL.HCL
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|---|---|
| Molecular Weight |
337.28668
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| Exact Mass |
336.115
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| CAS # |
14362-31-3
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| Related CAS # |
Chlorcyclizine;82-93-9
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| PubChem CID |
62413
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| Appearance |
White to off-white solid powder
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| Density |
1.145g/cm3
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| Boiling Point |
393.6ºC at 760mmHg
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| Flash Point |
191.9ºC
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| Vapour Pressure |
2.1E-06mmHg at 25°C
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| Index of Refraction |
1.59
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| LogP |
4.354
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
22
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| Complexity |
300
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
MSIJLVMSKDXAQN-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C18H21ClN2.ClH/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16;/h2-10,18H,11-14H2,1H3;1H
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| Chemical Name |
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine;hydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~77.5 mg/mL (~229.77 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.58 mg/mL (7.65 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.58 mg/mL (7.65 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.58 mg/mL (7.65 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.9648 mL | 14.8240 mL | 29.6481 mL | |
| 5 mM | 0.5930 mL | 2.9648 mL | 5.9296 mL | |
| 10 mM | 0.2965 mL | 1.4824 mL | 2.9648 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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