| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| Other Sizes |
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| ln Vitro |
Chelidonic acid suppresses IL-6 mRNA expression at 1–10 μM and dose-dependently lowers IL-6 production at 0.1–10 μM [1]. Chelidonic acid (0.1–10 μM) increases cytoplasmic NF-κB activation and decreases caspase-1 and nuclear NF-κB activation [1]. Chelidonic acid has a Ki of 1.2 μM, making it an inhibitor of glutamate decarboxylase. Chelidonic acid does not react with free pyridoxal-P or encourage the synthesis of apoenzymes [2].
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|---|---|
| ln Vivo |
Chelidonic acid (0.2, 2 mg/kg, orally) can lessen ovalbumin-induced allergy responses in mice [3].
|
| References |
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| Additional Infomation |
Chelidonic acid is a carbonyl compound and a member of pyrans.
Chelidonic acid has been reported in Zea mays, Chelidonium majus, and other organisms with data available. See also: Chelidonium majus flowering top (part of). |
| Molecular Formula |
C7H4O6
|
|---|---|
| Molecular Weight |
184.1031
|
| Exact Mass |
184.001
|
| CAS # |
99-32-1
|
| PubChem CID |
7431
|
| Appearance |
Gray to brown solid powder
|
| Density |
1.821 g/cm3
|
| Boiling Point |
471.3ºC at 760 mmHg
|
| Melting Point |
265 °C (dec.)(lit.)
|
| Flash Point |
204.1ºC
|
| LogP |
0.036
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
6
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
13
|
| Complexity |
316
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
PBAYDYUZOSNJGU-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C7H4O6/c8-3-1-4(6(9)10)13-5(2-3)7(11)12/h1-2H,(H,9,10)(H,11,12)
|
| Chemical Name |
4-oxopyran-2,6-dicarboxylic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~10 mg/mL (~54.32 mM)
H2O : ~2.5 mg/mL (~13.58 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (13.58 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (13.58 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: 2 mg/mL (10.86 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication (<60°C). |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.4318 mL | 27.1592 mL | 54.3183 mL | |
| 5 mM | 1.0864 mL | 5.4318 mL | 10.8637 mL | |
| 10 mM | 0.5432 mL | 2.7159 mL | 5.4318 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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