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Ch55 (Ch-55) is a synthetic retinoid acting as an inducer of teratocarcinoma cells by binding to RAR-α and RAR-β receptors with high affinity. Ch55 displays anticancer activity.
| ln Vitro |
Ch55 increases dissolved sulfate levels (EC50=0.03 nM) and inhibits type I transglutaminase activity (EC50=0.02 nM) to prevent squamous cell blanking of rabbit tracheal epithelial cells. Additionally, Ch55 suppresses the induction of avian dye decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM) and stimulates secretion from cancer F9 cells and melanoma S91 cells (EC50s=0.26 and 0.5 nM) [1].
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| References |
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| Additional Infomation |
4-[3-(3,5-ditert-butylphenyl)-3-oxoprop-1-enyl]benzoic acid is a member of chalcones.
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| Molecular Formula |
C24H28O3
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|---|---|
| Molecular Weight |
364.485
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| Exact Mass |
364.204
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| CAS # |
110368-33-7
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| PubChem CID |
6184667
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| Appearance |
White to light yellow solid powder
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| Density |
1.085g/cm3
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| Boiling Point |
509.5ºC at 760mmHg
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| Flash Point |
276ºC
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| Vapour Pressure |
3.33E-11mmHg at 25°C
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| Index of Refraction |
1.574
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| LogP |
5.875
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
27
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| Complexity |
531
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CC(C)(C)C1=CC(=CC(=C1)C(=O)/C=C/C2=CC=C(C=C2)C(=O)O)C(C)(C)C
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| InChi Key |
FOUVTBKPJRMLPE-FMIVXFBMSA-N
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| InChi Code |
InChI=1S/C24H28O3/c1-23(2,3)19-13-18(14-20(15-19)24(4,5)6)21(25)12-9-16-7-10-17(11-8-16)22(26)27/h7-15H,1-6H3,(H,26,27)/b12-9+
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| Chemical Name |
4-[(E)-3-(3,5-ditert-butylphenyl)-3-oxoprop-1-enyl]benzoic acid
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| Synonyms |
Ch 55 Ch-55 Ch55
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~137.18 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.86 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7436 mL | 13.7178 mL | 27.4356 mL | |
| 5 mM | 0.5487 mL | 2.7436 mL | 5.4871 mL | |
| 10 mM | 0.2744 mL | 1.3718 mL | 2.7436 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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