| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| Other Sizes |
| Targets |
Cetrimonium bromide targets microbial cell membranes, disrupting their integrity and function. As a cationic surfactant, it interacts with the negatively charged components of bacterial and fungal cell membranes, leading to increased permeability, leakage of cellular contents, and cell death. This broad-spectrum antimicrobial activity makes it effective against bacteria and fungi.
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|---|---|
| ln Vitro |
In vitro, cetrimonium bromide exhibits antimicrobial activity against a variety of bacteria and fungi. It is used as a cationic detergent and antiseptic in various research and industrial applications. Its ability to disrupt cell membranes makes it a valuable tool for studying membrane biology and antimicrobial mechanisms.
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| ln Vivo |
In vivo, cetrimonium bromide is used as an antiseptic in topical applications and as a disinfectant in various settings. It is also used in hair conditioning products due to its cationic surfactant properties. However, its use is primarily external, and it is not typically administered systemically.
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| Enzyme Assay |
In vitro enzyme/receptor binding assays are not typically performed for cetrimonium bromide as it does not have a specific enzymatic target. Its activity is assessed by measuring its antimicrobial efficacy against bacterial and fungal cultures using minimum inhibitory concentration (MIC) assays. The compound is incubated with microbial cultures, and the growth inhibition is measured.
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| Cell Assay |
For in vitro cell-based assays, cetrimonium bromide is dissolved in aqueous buffers and applied to cultured cells at concentrations ranging from 1-100 µg/mL. The effects on cell viability and membrane integrity are assessed using standard assays such as MTT or lactate dehydrogenase (LDH) release. Its ability to disrupt cell membranes is also evaluated using fluorescence-based assays.
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| Animal Protocol |
In vivo animal studies for cetrimonium bromide are typically toxicological or efficacy studies in rodent models. The compound is administered topically or orally at doses ranging from 1-100 mg/kg. Skin irritation, systemic toxicity, and antimicrobial efficacy are evaluated. However, detailed in vivo data for cetrimonium bromide are not extensively published in the public domain.
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| ADME/Pharmacokinetics |
Cetrimonium bromide has a molecular formula of C₁₉H₄₂BrN and a molecular weight of 364.45 g/mol. It is a white to off-white powder with a melting point of 237-243°C. It is soluble in water and organic solvents. The compound is typically stored at ambient temperature.
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| Toxicity/Toxicokinetics |
Cetrimonium bromide is considered to have a manageable toxicity profile. It is a skin and eye irritant, and appropriate safety precautions, including the use of personal protective equipment, should be followed when handling the compound. Inhalation and ingestion should be avoided. The compound is classified as dangerous for transport.
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| References |
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| Additional Infomation |
Cetyltrimethylammonium bromide is the bromide of Cetyltrimethylammonium and a component of the topical disinfectant Cetyltrimethylammonium bromide. It acts as a surfactant and detergent. It is a quaternary ammonium salt and organic bromide containing the Cetyltrimethylammonium ion. Cetyltrimethylammonium compounds, their salts, and derivatives are primarily used as topical disinfectants. See also: Cetyltrimethylammonium (with active moiety); Cetyltrimethylammonium bromide (note moved to).
Cetrimonium bromide is a cationic surfactant and antiseptic agent widely used in research, industrial, and cosmetic applications. It is also known as hexadecyltrimethylammonium bromide or CTAB. Cetrimonium bromide is not a therapeutic drug and is intended for research and industrial use only. It is supplied by various chemical suppliers for non-human use. |
| Molecular Formula |
C19H42BRN
|
|---|---|
| Molecular Weight |
363.46
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| Exact Mass |
363.25
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| CAS # |
57-09-0
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| Related CAS # |
Cetrimonium bromide-d42;907216-28-8;Cetrimonium-d33 bromide;347841-42-3;Cetrimonium-d3 bromide;1092921-73-7;Cetrimonium-d9 bromide;95217-14-4
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| PubChem CID |
5974
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| Appearance |
White to off-white solid powder
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| Melting Point |
248-251 °C(lit.)
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| Flash Point |
244 °C
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| LogP |
3.177
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
15
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| Heavy Atom Count |
21
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| Complexity |
181
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
LZZYPRNAOMGNLH-UHFFFAOYSA-M
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| InChi Code |
InChI=1S/C19H42N.BrH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(2,3)4;/h5-19H2,1-4H3;1H/q+1;/p-1
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| Chemical Name |
hexadecyl(trimethyl)azanium;bromide
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| Synonyms |
NSC-32927; NSC 32927; Cetrimonium bromide
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~10 mg/mL (~27.44 mM)
H2O : ~4.55 mg/mL (~12.48 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1 mg/mL (2.74 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 10.0 mg/mL clear DMSO stock solution to 400 μL of PEG300 and mix evenly; then add 50 μL of Tween-80 to the above solution and mix evenly; then add 450 μL of normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1 mg/mL (2.74 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 10.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 1 mg/mL (2.74 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 50 mg/mL (137.19 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7513 mL | 13.7567 mL | 27.5133 mL | |
| 5 mM | 0.5503 mL | 2.7513 mL | 5.5027 mL | |
| 10 mM | 0.2751 mL | 1.3757 mL | 2.7513 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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