| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Microbial cell membranes. Cetalkonium chloride acts as a disinfectant and preservative by disrupting microbial cell integrity. It is a quaternary ammonium compound that disrupts microbial cell membranes. Cetalkonium chloride is a quaternary ammonium compound with broad-spectrum antimicrobial activity.
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|---|---|
| ln Vitro |
Cetalkonium chloride has broad-spectrum antimicrobial activity. It is used as a preservative and disinfectant in various applications, including ophthalmic and skin care formulations. It acts as an anti-inflammatory amphiphilic agent. Cetalkonium chloride is an ammonium antiseptic agent used in many topical drugs for infections of mouth, throat, and eye.
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| ln Vivo |
Cetalkonium chloride is used in many topical agents for infections of mouth, throat, and eye. Its in vivo activity is established through its use in topical formulations for treating infections. Cetalkonium chloride is used in many topical drugs for infections of mouth, throat, and eye.
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| Enzyme Assay |
Specific protocols for in vitro antimicrobial assays for Cetalkonium chloride are not detailed. Its activity is typically assessed using standard microbiological susceptibility testing, such as minimum inhibitory concentration (MIC) determinations against various bacterial and fungal strains.
|
| Cell Assay |
Cellular assays for Cetalkonium chloride are not typical. Its antimicrobial activity is evaluated in microbiological assays using bacterial and fungal cultures. Cetalkonium chloride has broad-spectrum antimicrobial activity.
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| Animal Protocol |
Cetalkonium chloride is used in topical formulations for the treatment of infections. Its in vivo efficacy is established through its use in these products. Cetalkonium chloride is used in many topical agents for infections of mouth, throat, and eye.
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| ADME/Pharmacokinetics |
Cetalkonium chloride is a topical agent. Specific pharmacokinetic data is not available in the provided references. As a topical agent, it is not significantly absorbed systemically.
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| Toxicity/Toxicokinetics |
Cetalkonium chloride is generally safe for topical use. It can cause local irritation or allergic reactions in some individuals. Systemic toxicity is unlikely with topical application.
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| References | |
| Additional Infomation |
Cetalkonium chloride is a quaternary ammonium compound used as a preservative and antiseptic agent. It is used in various pharmaceutical and cosmetic products. Cetalkonium chloride (CAS#: 122-18-9) is a quaternary ammonium compound with broad-spectrum antimicrobial activity.
|
| Molecular Formula |
C25H46CLN
|
|---|---|
| Molecular Weight |
396.0924
|
| Exact Mass |
395.331
|
| CAS # |
122-18-9
|
| Related CAS # |
122-18-9 (Cl);10328-34-4;
|
| PubChem CID |
31202
|
| Appearance |
White to off-white solid powder
|
| Melting Point |
55-65 °C(lit.)
|
| LogP |
4.748
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
17
|
| Heavy Atom Count |
27
|
| Complexity |
291
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
SXPWTBGAZSPLHA-UHFFFAOYSA-M
|
| InChi Code |
InChI=1S/C25H46N.ClH/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-20-23-26(2,3)24-25-21-18-17-19-22-25;/h17-19,21-22H,4-16,20,23-24H2,1-3H3;1H/q+1;/p-1
|
| Chemical Name |
benzyl-hexadecyl-dimethylazanium;chloride
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~252.47 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.31 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (6.31 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (6.31 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5247 mL | 12.6234 mL | 25.2468 mL | |
| 5 mM | 0.5049 mL | 2.5247 mL | 5.0494 mL | |
| 10 mM | 0.2525 mL | 1.2623 mL | 2.5247 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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