| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
| Toxicity/Toxicokinetics |
Effects During Pregnancy and Lactation
◉ Overview of Use During Lactation Cefotetan has been discontinued in the United States. Current information indicates that cefotetan is present in low concentrations in breast milk and is not expected to have adverse effects on breastfed infants. There have been reports that cephalosporins occasionally disrupt the gut microbiota of infants, leading to diarrhea or thrush, but these effects have not been fully assessed. Cefotetan is safe for use by breastfeeding women. ◉ Effects on Breastfed Infants No published information found as of the revision date. ◉ Effects on Breastfeeding and Breast Milk No published information found as of the revision date. |
|---|---|
| Additional Infomation |
Cefotetan is a semi-synthetic second-generation cephalosporin antibiotic. Its cephalosporin skeleton has [(1-methyl-1H-tetrazol-5-yl)thio]methyl, methoxy, and {[4-(2-amino-1-carboxy-2-oxoethylene)-1,3-dithionecyclobutane-2-yl]carbonyl}amino groups attached to the 3, 7α, and 7β positions, respectively. It is resistant to many β-lactamases and is effective against a variety of aerobic and anaerobic Gram-positive and Gram-negative bacteria. It is an antibacterial drug. It is the conjugate acid of cefotetan (2-). Cefotetan is a cephalosporin antibiotic. The effects of cefotetan in bovine (Bos taurus) have been reported, and relevant data are available. Cefotetan is a semi-synthetic cephalosporin antibiotic that can be administered intravenously or intramuscularly. This drug exhibits high resistance to various β-lactamases and is effective against a wide range of aerobic and anaerobic Gram-positive and Gram-negative bacteria.
See also: Cefotetan (note moved to). |
| Molecular Formula |
C17H17N7O8S4
|
|---|---|
| Molecular Weight |
575.6190
|
| Exact Mass |
575.002
|
| CAS # |
69712-56-7
|
| Related CAS # |
Cefotetan disodium;74356-00-6
|
| PubChem CID |
53025
|
| Appearance |
White to off-white solid powder
|
| Density |
2.1±0.1 g/cm3
|
| Melting Point |
173-178ºC (dec.)
|
| Index of Refraction |
1.921
|
| LogP |
2.34
|
| Hydrogen Bond Donor Count |
4
|
| Hydrogen Bond Acceptor Count |
15
|
| Rotatable Bond Count |
9
|
| Heavy Atom Count |
36
|
| Complexity |
1090
|
| Defined Atom Stereocenter Count |
2
|
| SMILES |
S1C([H])([H])C(C([H])([H])SC2=NN=NN2C([H])([H])[H])=C(C(=O)O[H])N2C([C@]([C@@]12[H])(N([H])C(C1([H])S/C(=C(/C(=O)O[H])\C(N([H])[H])=O)/S1)=O)OC([H])([H])[H])=O
|
| InChi Key |
SRZNHPXWXCNNDU-RHBCBLIFSA-N
|
| InChi Code |
InChI=1S/C17H17N7O8S4/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30)/t13?,15-,17+/m1/s1
|
| Chemical Name |
(6R,7S)-7-[[4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietane-2-carbonyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~250 mg/mL (~434.31 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.25 mg/mL (2.17 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1.25 mg/mL (2.17 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 1.25 mg/mL (2.17 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7373 mL | 8.6863 mL | 17.3726 mL | |
| 5 mM | 0.3475 mL | 1.7373 mL | 3.4745 mL | |
| 10 mM | 0.1737 mL | 0.8686 mL | 1.7373 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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