| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
|
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| 100mg | |||
| Other Sizes |
| ADME/Pharmacokinetics |
Biological Half-Life
The half-life after intravenous injection is 32 minutes; the half-life after intramuscular injection is 60 minutes. |
|---|---|
| Toxicity/Toxicokinetics |
Protein Binding
75% |
| Additional Infomation |
Cefamandole is a cephalosporin compound with an (R)-mandelicamide group and an N-methylthiotetrazole side group. It is an antibacterial drug. It is a semi-synthetic cephalosporin derivative, the conjugate acid of cefamandole (1-). Cefamandole is also known as cefamandole. It is a broad-spectrum cephalosporin antibiotic administered parenterally. It is usually formulated as a formate, namely [cefamandole naphthylcarbamate]. It is no longer sold in the United States. There are reports of cefamandole being found in honeybees, and relevant data exist. Cefamandole is a second-generation cephalosporin antibiotic with bactericidal activity. Cefamandole is effective against Haemophilus influenzae and Gram-negative bacilli sensitive to other cephalosporins. It is also effective against many other cephalosporin-resistant strains, such as Enterobacter spp. and indole-positive Proteus spp. A semi-synthetic broad-spectrum cephalosporin with a long-lasting effect, possibly due to β-lactamase resistance. It is also available as a naphthylcarbamate. Indications For the treatment of severe infections caused by susceptible microbial strains. Mechanism of Action Like all β-lactam antibiotics, cefamandole binds to a specific penicillin-binding protein (PBP) located within the bacterial cell wall, thereby inhibiting the third (and final) stage of bacterial cell wall synthesis. Bacterial cell wall autolysins (such as autolysins) then mediate cell lysis; cefamandole may interfere with the action of autolysin inhibitors. Pharmacodynamics Cefmandole formate is a broad-spectrum cephalosporin antibiotic administered by injection. The bactericidal effect of cefamandole stems from its inhibition of cell wall synthesis. Cephalosporins are active in vitro against a wide range of Gram-positive and Gram-negative bacteria.
|
| Molecular Formula |
C18H17N6O5S2-.NA+
|
|---|---|
| Molecular Weight |
484.48458
|
| Exact Mass |
484.059
|
| CAS # |
30034-03-8
|
| Related CAS # |
Cefamandole;34444-01-4;Cefamandole nafate;42540-40-9
|
| PubChem CID |
456255
|
| Appearance |
White to off-white solid powder
|
| Melting Point |
>175ºC (dec.)
|
| LogP |
-0.9
|
| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
10
|
| Rotatable Bond Count |
7
|
| Heavy Atom Count |
31
|
| Complexity |
777
|
| Defined Atom Stereocenter Count |
3
|
| SMILES |
O=C(C(N12)=C(CSC3=NN=NN3C)CS[C@]2([H])[C@H](NC([C@H](O)C4=CC=CC=C4)=O)C1=O)[O-].[Na+]
|
| InChi Key |
OLVCFLKTBJRLHI-AXAPSJFSSA-N
|
| InChi Code |
InChI=1S/C18H18N6O5S2/c1-23-18(20-21-22-23)31-8-10-7-30-16-11(15(27)24(16)12(10)17(28)29)19-14(26)13(25)9-5-3-2-4-6-9/h2-6,11,13,16,25H,7-8H2,1H3,(H,19,26)(H,28,29)/t11-,13-,16-/m1/s1
|
| Chemical Name |
(6R,7R)-7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~250 mg/mL (~516.02 mM)
DMSO : ~50 mg/mL (~103.20 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.16 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (5.16 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (5.16 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 100 mg/mL (206.41 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0641 mL | 10.3203 mL | 20.6407 mL | |
| 5 mM | 0.4128 mL | 2.0641 mL | 4.1281 mL | |
| 10 mM | 0.2064 mL | 1.0320 mL | 2.0641 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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