| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 10mg |
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| 50mg |
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| Other Sizes |
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| ln Vitro |
For Rpn11, Capzimin (3027) exhibits selectivity 80 times greater than that of Csn5, 10 times greater than that of AMSH, and 6 times greater than that of BRCC36 (IC50=30 μM, 4.5 μM, and 2.3 μM, respectively). Screening for sixty refractive index systems was done using Capzimin. NCI group. The GI50 median is 3.3 μM. Capzimin shows good activity in a range of solid tumor cell lines, such as NCI-H460 (non-small cell lung cancer; GI50= 0.7 μM) and MCF7 (breast cancer; GI50= 1.0 μM), as well as blood cells, such as the SR and K562 cell lines (GI50 values of 0.67 μM and 1 μM, respectively). Capzimin both stimulates and inhibits the growth of cells, as demonstrated by the Western blot validation of processed forms of caspase 3 and caspase-cleaved polyADP-ribose polymerase in HCT116 cells [1].
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|---|---|
| References |
| Molecular Formula |
C30H24N6O2S4
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|---|---|
| Molecular Weight |
628.81056022644
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| Exact Mass |
628.084
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| CAS # |
2084868-04-0
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| Related CAS # |
Rpn11-IN-1;2084867-65-0
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| PubChem CID |
126599606
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| Appearance |
White to yellow solid powder
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| LogP |
5.2
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
10
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| Rotatable Bond Count |
11
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| Heavy Atom Count |
42
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| Complexity |
834
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O=C(C1C=C2C(C(=CC=C2)SSC2C3C(=CC(C(NCCC4SC=CN=4)=O)=CN=3)C=CC=2)=NC=1)NCCC1SC=CN=1
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| InChi Key |
RNEOHKZPZKEZCQ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C30H24N6O2S4/c37-29(33-9-7-25-31-11-13-39-25)21-15-19-3-1-5-23(27(19)35-17-21)41-42-24-6-2-4-20-16-22(18-36-28(20)24)30(38)34-10-8-26-32-12-14-40-26/h1-6,11-18H,7-10H2,(H,33,37)(H,34,38)
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| Chemical Name |
N-[2-(1,3-thiazol-2-yl)ethyl]-8-[[3-[2-(1,3-thiazol-2-yl)ethylcarbamoyl]quinolin-8-yl]disulfanyl]quinoline-3-carboxamide
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 55.67 mg/mL (~88.53 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (3.98 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (3.98 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.5903 mL | 7.9515 mL | 15.9031 mL | |
| 5 mM | 0.3181 mL | 1.5903 mL | 3.1806 mL | |
| 10 mM | 0.1590 mL | 0.7952 mL | 1.5903 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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