| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Caprylic/capric triglyceride does not have a pharmacological target. It is an inert substance used as a pharmaceutical excipient. Its primary function is as a solvent, carrier, and emulsifier for active pharmaceutical ingredients (APIs). It is often used to solubilize lipophilic drugs and to improve their bioavailability. It is also used as a skin conditioning agent in cosmetics.
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|---|---|
| ln Vitro |
In vitro, caprylic/capric triglyceride is used as a solvent and vehicle for poorly water-soluble compounds. It is used in the preparation of drug solutions, emulsions, and microemulsions. Its ability to enhance the solubility and permeability of drugs can be assessed using in vitro dissolution and permeability assays (e.g., Caco-2 cell models).
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| ln Vivo |
Caprylic/capric triglyceride is not used for in vivo therapeutic activity on its own. It is used as a carrier or vehicle for other drugs. For example, it can be used in oral, topical, or parenteral formulations to deliver the active drug. Its role in vivo is to provide a safe and effective means of drug delivery, and it is generally considered to be non-toxic and well-tolerated.
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| Enzyme Assay |
Caprylic/capric triglyceride does not have an enzyme or receptor binding assay because it has no biological target. Its characterization involves physicochemical testing, such as determination of its fatty acid composition, acid value, saponification value, and peroxide value. These tests ensure its purity and suitability as an excipient.
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| Cell Assay |
In vitro cellular assays for caprylic/capric triglyceride are used to assess its safety and potential for irritation. For example, its cytotoxicity can be tested on various cell lines (e.g., fibroblasts, keratinocytes) using MTT assays. Its irritation potential can be evaluated using the Hen's Egg Test - Chorioallantoic Membrane (HET-CAM) assay or reconstructed human epidermis models.
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| Animal Protocol |
Caprylic/capric triglyceride is not used in in vivo animal experiments as a drug. However, it is used in animal studies as a vehicle for other compounds. In such studies, the animal is administered the formulation containing the active drug dissolved in caprylic/capric triglyceride, and the pharmacokinetics and efficacy of the drug are evaluated. The triglyceride itself is considered an inert vehicle.
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| ADME/Pharmacokinetics |
Caprylic/capric triglyceride is a lipophilic substance that is not absorbed intact to a significant extent. It is hydrolyzed in the gastrointestinal tract by lipases to its constituent fatty acids and glycerol. These are then absorbed and metabolized as normal dietary fats. It is not stored in the body to any significant degree. Its metabolism follows that of medium-chain triglycerides (MCTs).
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| Toxicity/Toxicokinetics |
Caprylic/capric triglyceride is generally recognized as safe (GRAS) by the FDA. It has low acute toxicity and is not a skin irritant, sensitizer, or mutagen. It is well-tolerated when used as a pharmaceutical excipient. No significant adverse effects are associated with its use at the concentrations employed in pharmaceutical and cosmetic products.
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| References | |
| Additional Infomation |
Caprylic/capric triglyceride is also known as medium-chain triglyceride (MCT) oil, octanoic/decanoic triglyceride, and glyceryl tricaprylate/caprate. It is a widely used excipient in pharmaceutical formulations for oral, topical, and parenteral administration. It is also a common ingredient in cosmetics, lotions, creams, and hair care products. It is valued for its excellent solvent properties, oxidative stability, and skin compatibility.
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| Molecular Formula |
C21H40O5
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|---|---|
| Molecular Weight |
372.54
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| Exact Mass |
372.287
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| CAS # |
65381-09-1
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| Appearance |
Colorless to light yellow liquid
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| Density |
1.0±0.1 g/cm3
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| Boiling Point |
456.0±12.0 °C at 760 mmHg
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| Flash Point |
142.6±13.1 °C
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| Vapour Pressure |
0.0±2.5 mmHg at 25°C
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| Index of Refraction |
1.462
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| LogP |
6.9
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| SMILES |
C(O)(CO)CO.C(CC(=O)O)CCCCC.C(CCC(=O)O)CCCCCC
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (Infinity mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6843 mL | 13.4214 mL | 26.8428 mL | |
| 5 mM | 0.5369 mL | 2.6843 mL | 5.3686 mL | |
| 10 mM | 0.2684 mL | 1.3421 mL | 2.6843 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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