| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
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| Other Sizes |
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| ln Vitro |
Buthionine suLfoximine is a methionine suLfoximine analogue that exhibits at least 100 times the efficiency of methionine suLfoximine in inhibiting γ-glutamylcysteine synthetase, compared to around 20 times that of methionine suLfoximine [1].
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|---|---|
| ln Vivo |
A continuous intravenous infusion of non-toxic dosages of D,L-buthionine-(S,R)-imine (300 and 600 mg/kg/day) was administered to mice containing HT1080 and HT1080/DR4 xenografts. GSH tumor levels are decreased by more than 95% in multidrug additions and commonly decrease by 60% in parent cancers [2].
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| References |
[1]. Griffith OW, et al. Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J Biol Chem. 1979 Aug 25;254(16):7558-60.
[2]. Vanhoefer U, et al. d,l-buthionine-(S,R)-sulfoximine potentiates in vivo the therapeutic efficacy of doxorubicin against multidrug resistance protein-expressing tumors. Clin Cancer Res. 1996 Dec;2(12):1961-8 |
| Molecular Formula |
C8H18N2O3S
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|---|---|
| Molecular Weight |
222.303
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| Exact Mass |
222.1038
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| CAS # |
5072-26-4
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| Related CAS # |
L-Buthionine-(S,R)-sulfoximine;83730-53-4;DL-Buthionine-(S,R)-sulfoximine hydrochloride;L-Buthionine-(S,R)-sulfoximine hydrochloride
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| SMILES |
OC(C(N)CCS(CCCC)(=N)=O)=O
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| Synonyms |
Buthionine Sulphoximine; BSO; NSC-326231
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~25 mg/mL (~112.46 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (449.82 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.4984 mL | 22.4921 mL | 44.9843 mL | |
| 5 mM | 0.8997 mL | 4.4984 mL | 8.9969 mL | |
| 10 mM | 0.4498 mL | 2.2492 mL | 4.4984 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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