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    BTB06584
    BTB06584

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0191
    CAS #: 219793-45-0Purity ≥98%

    Description: BTB06584 (BTB-06584; BTB 06584) is a novel, potent and IF1-dependent inhibitor of the mitochondrial F1 Fo-ATPase, acting by selectively inhibiting mitochondrial F1 Fo-ATPase activity without compromising ATP synthesis and to limit ischaemia-induced injury caused by reversal of the mitochondrial F1 Fo-ATPsynthase.  

    References: Br J Pharmacol. 2014 Sep;171(18):4193-206.

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    Molecular Weight (MW)417.82
    FormulaC19H12ClNO6S
    CAS No.219793-45-0
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 84 mg/mL (201.0 mM)
    Water: <1 mg/mL 
    Ethanol: <1 mg/mL 
    Other info

    Chemical Name: 2-nitro-5-(phenylsulfonyl)phenyl 4-chlorobenzoate

    InChi Key: WNDWKKPBLAKXMI-UHFFFAOYSA-N

    InChi Code: InChI=1S/C19H12ClNO6S/c20-14-8-6-13(7-9-14)19(22)27-18-12-16(10-11-17(18)21(23)24)28(25,26)15-4-2-1-3-5-15/h1-12H

    SMILES Code: O=S(C1=CC(OC(C2=CC=C(Cl)C=C2)=O)=C([N+]([O-])=O)C=C1)(C3=CC=CC=C3)=O

    SynonymsBTB06584; BTB 06584; BTB-06584


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    In Vitro

    In vitro activity: BTB06584 IF1-dependently inhibits F1 Fo-ATPase activity with no effect on without compromising ATP synthesis, and also limits ischemia-induced injury caused by reversal of the mitochondrial F1 Fo-ATP synthase.


    Cell Assay: BTB inhibited F1Fo-ATPase activity with no effect on the mitochondrial membrane potential (ΔΨm) or O2 consumption. ATP consumption decreased via inhibition of respiration, and ischaemic cell death was reduced. BTB efficiency increased by IF1 overexpression and reduced by silencing this protein. In addition, BTB rescued defective haemoglobin synthesis in zebrafish pinotage (pnt) mutants in which expression of the Atpif1a gene is lost.

    In VivoBTB06584 rescues the defective haemoglobin synthesis in zebrafish pinotage (pnt) mutants without causing significant toxicity. 
    Animal modelzebrafish pinotage
    Formulation & DosageN/A
    References

    Br J Pharmacol. 2014 Sep;171(18):4193-206.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    BTB06584

    Mitochondrial network morphology in BTB-treated cells and IF1 dimers/tetramers ratio. Br J Pharmacol. 2014 Sep;171(18):4193-206.
     

    BTB06584

    BTB-mediated rescue of haemoglobin synthesis in pnt zebrafish embryos. Br J Pharmacol. 2014 Sep;171(18):4193-206.


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