| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
|
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| Other Sizes |
| Targets |
Metal ions, such as iron and copper, which are essential for microbial growth and enzyme function. Broxyquinoline chelates these metal ions, thereby inhibiting the activity of metal-dependent enzymes and disrupting microbial metabolism.
|
|---|---|
| ln Vitro |
Broxyquinoline has demonstrated antibacterial and antifungal activity in vitro. It is effective against a range of Gram-positive and Gram-negative bacteria, as well as fungi. Its metal-chelating properties have been characterized.
|
| ln Vivo |
In vivo, broxyquinoline has been used as an antiseptic and disinfectant for topical applications. Its use as a therapeutic agent is limited due to its toxicity.
|
| Enzyme Assay |
In vitro assays for broxyquinoline involve measuring its antibacterial and antifungal activity using standard microbiological methods. Its metal-chelating properties can be assessed using spectrophotometric methods.
|
| Cell Assay |
Cellular assays for broxyquinoline are not applicable, as it is not a therapeutic agent for systemic use.
|
| Animal Protocol |
In vivo animal studies for broxyquinoline are limited. Its use is primarily as a topical antiseptic.
|
| ADME/Pharmacokinetics |
Metabolism / Metabolites
Bromine is primarily absorbed through inhalation, but can also enter the body through skin contact. Bromine salts can be ingested. Due to its reactivity, bromine rapidly forms bromides and may deposit in tissues, displacing other halogens. (L626) Pharmacokinetic data for broxyquinoline is limited. As a topical agent, systemic absorption is minimal. |
| Toxicity/Toxicokinetics |
Toxicity Summary
Bromine is a strong oxidizing agent that can release oxygen free radicals from water in mucous membranes. These free radicals are also strong oxidizing agents and can cause tissue damage. Furthermore, bromine can generate hydrobromic acid and bromic acid, leading to secondary irritation. Bromine ions can also affect the central nervous system, causing bromine poisoning. This is believed to be due to bromide ions replacing chloride ions in the action of neurotransmitters and transport systems, thereby affecting various synaptic processes. (L626, L627, A543) Broxyquinoline is considered toxic and should be handled with caution. It can cause skin irritation and sensitization. |
| References |
|
| Additional Infomation |
5,7-Dibromo-8-quinolinol belongs to the quinoline family and is an organohalide. Bromoquinoline is an organobromine used as an anti-infective drug. Bromine is a halogen element with the symbol Br and atomic number 35. Diatomic bromine does not exist in nature, but its bromide salts are found in Earth's crustal rocks. (L625, L689)
Broxyquinoline (5,7-dibromo-8-hydroxyquinoline) is a quinoline derivative with antibacterial and antifungal properties. It has been used as an antiseptic and disinfectant. Its mechanism of action involves the chelation of metal ions. |
| Molecular Formula |
C9H5BR2NO
|
|---|---|
| Molecular Weight |
302.953
|
| Exact Mass |
300.873
|
| CAS # |
521-74-4
|
| PubChem CID |
2453
|
| Appearance |
Yellow to brown solid powder
|
| Density |
2.1±0.1 g/cm3
|
| Boiling Point |
370.5±37.0 °C at 760 mmHg
|
| Melting Point |
198-200 °C(lit.)
|
| Flash Point |
177.9±26.5 °C
|
| Vapour Pressure |
0.0±0.9 mmHg at 25°C
|
| Index of Refraction |
1.739
|
| LogP |
4.09
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
0
|
| Heavy Atom Count |
13
|
| Complexity |
191
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
ZDASUJMDVPTNTF-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C9H5Br2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
|
| Chemical Name |
5,7-dibromoquinolin-8-ol
|
| Synonyms |
NSC-1810; NSC 1810; Broxyquinoline
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~31.25 mg/mL (~103.15 mM)
H2O : ~0.67 mg/mL (~2.21 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.08 mg/mL (6.87 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1.67 mg/mL (5.51 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 16.7 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3009 mL | 16.5044 mL | 33.0087 mL | |
| 5 mM | 0.6602 mL | 3.3009 mL | 6.6017 mL | |
| 10 mM | 0.3301 mL | 1.6504 mL | 3.3009 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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