| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
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| ln Vitro |
As early as two hours after treating MM1S cells, BRD9876 (10 μM; 24 hours) rapidly arrests cells in the G2/M phase [1]. Compared to CD34+-derived hematopoietic cells (IC50=9.1 μM), BRD9876 is around three times more selective for MM1S myeloma cells (IC50=3.1 μM) [1]. The stromal resistance of bone marrow stromal cells (BMSCs) from MM bone marrow aspirates in MM1S cells can be overcome by BRD9876 (0.1, 1, 10, 100 uM); however, BRD9876 has very little effect on primary MM cells [1]. While cyclic L5 paired with monastrol or α4/α6 combined with BI8 display higher activity on baseline Eg5 ATPase activity, BRD9876 is absolutely ineffective in reducing this activity [1].
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|---|---|
| Cell Assay |
Cell cycle analysis [1]
Cell Types: MM1S cells and CD34 hematopoietic cells Tested Concentrations: 10 μM Incubation Duration: 24 hrs (hours) Experimental Results: In MM1S cells, cells rapidly arrested in the G2/M phase as early as 2 hrs (hours) after treatment. The G2/M phase arrest of CD34 hematopoietic cells was Dramatically diminished. |
| References |
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| Additional Infomation |
6-tert-butylnaphthalene-2,3-dicarbonitrile is a member of naphthalenes.
|
| Molecular Formula |
C16H14N2
|
|---|---|
| Molecular Weight |
234.3
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| Exact Mass |
234.116
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| CAS # |
32703-82-5
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| PubChem CID |
613000
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| Appearance |
White to yellow solid powder
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| Density |
1.11g/cm3
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| Boiling Point |
429.7ºC at 760 mmHg
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| Melting Point |
185-189ºC(lit.)
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| Flash Point |
206.6ºC
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| Index of Refraction |
1.603
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| LogP |
3.88
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
18
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| Complexity |
400
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| Defined Atom Stereocenter Count |
0
|
| InChi Key |
MKILROQBJOOZKC-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H14N2/c1-16(2,3)15-5-4-11-6-13(9-17)14(10-18)7-12(11)8-15/h4-8H,1-3H3
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| Chemical Name |
6-tert-butylnaphthalene-2,3-dicarbonitrile
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| Synonyms |
BRD 9876; BRD-9876; BRD9876
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~213.40 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (10.67 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.2680 mL | 21.3402 mL | 42.6803 mL | |
| 5 mM | 0.8536 mL | 4.2680 mL | 8.5361 mL | |
| 10 mM | 0.4268 mL | 2.1340 mL | 4.2680 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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