| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
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| ln Vitro |
Bradykinin is a powerful vasodilator peptide that causes the release of prostacyclin, NO, and EDHF by activating certain endothelium B2 receptors [1]. Bradykinin plays a role in the development of many malignancies. Treatment with bradykinin increases bradykinin, which in turn activates ERK1/2 and produces IL-6 [2]. In a dose-dependent manner, exogenous bradykinin markedly suppressed the mRNA and expression levels of LPS-induced TF. Bradykinin's inhibitory effect on tissue factor expression was greatly reduced by the PI3K coupling agent LY294002 and the synthase antagonist L-NAME [3].
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| ln Vivo |
When 1 μM bradykinin was used to assess pregnancy, the mean arterial pressure significantly decreased and hypocardia was seen. When 1 μM bradykinin was given to vagotomized rats, it caused hypocardia and hypotension, which are identical reactions as occur during vagotomy [4]. In cases of severe acute pancreatitis, bradykinin reduces hemorrhage and ischemic microcirculation. The pancreatic microcirculatory blood flow and flow rate in the group treated with bradykinin increased steadily over a 48-hour period [5]. Activation of the Akt signal amplifier inhibits TF expression by lowering the levels of NF-x03BA;B in the nucleus and decreasing the activities of GSK-3β and MAPK. In line with this, bradykinin injected intraperitoneally into C57/BL6 mice has the ability to stop thrombosis brought on by inferior vena cava ligation [3].
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| References |
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| Additional Infomation |
Bradykinin is a linear nonapeptide messenger belonging to the kinin group of proteins, with amino acid sequence RPPGFSPFR. Enzymatically produced from kallidin in the blood, it is a powerful vasodilator that causes smooth muscle contraction, and may mediate inflammation. It has a role as a human blood serum metabolite and a vasodilator agent. It is a conjugate base of a bradykinin(2+).
Bradykinin has been investigated for the basic science and treatment of Hypertension and Diabetes Type 2. Bradykinin has been reported in Rana temporaria and Pelophylax lessonae with data available. A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter. |
| Molecular Formula |
C57H81N13O12.C2HO2F3
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|---|---|
| Molecular Weight |
1254.35628
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| Exact Mass |
1059.561
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| CAS # |
58-82-2
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| Related CAS # |
biotin-Bradykinin;477319-71-4
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| PubChem CID |
439201
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| Appearance |
White to off-white solid powder
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| Density |
1.5±0.1 g/cm3
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| Melting Point |
170ºC
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| Index of Refraction |
1.693
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| LogP |
-0.82
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| Hydrogen Bond Donor Count |
12
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| Hydrogen Bond Acceptor Count |
14
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| Rotatable Bond Count |
27
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| Heavy Atom Count |
76
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| Complexity |
2080
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| Defined Atom Stereocenter Count |
8
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| SMILES |
C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)N)C(=O)NCC(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CO)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O
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| InChi Key |
QXZGBUJJYSLZLT-FDISYFBBSA-N
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| InChi Code |
InChI=1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
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| Chemical Name |
(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ≥ 100 mg/mL (~94.32 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (94.32 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.7972 mL | 3.9861 mL | 7.9722 mL | |
| 5 mM | 0.1594 mL | 0.7972 mL | 1.5944 mL | |
| 10 mM | 0.0797 mL | 0.3986 mL | 0.7972 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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