| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
|
||
| 5mg |
|
||
| Other Sizes |
|
BMS22 (BMS-22; BMS CCR2 22) is a novel and potent CCR2 (CC-type chemokine receptor 2) antagonist with anti-inflammatory activity. It has high binding affinity to CCR2 with IC50 of 5.1 nM.
| ln Vitro |
BMS CCR2 22 (compound 22) has binding affinity for wild type and E291A mutant with IC50 values of 7.5 nM and 3.7 nM respectively[1]. BMS CCR2 22 inhibits binding and internalization of fluorescently tagged hMCP-1_AF647 in human monocytes. BMS CCR2 22 inhibits the internalization of hMCP1_AF647 with an IC50 value of around 2 nM[2]. Addition of BMS CCR2 22 (0.1-10 μM; 24 hours), cenicriviroc (CVC), or the combination of BMS CCR2 22 and MVC to human aortic endothelial cells (HAoEC) prior to MCP-1 stimulation did not change E-selectin, ICAM -1 or CD99 cell surface expression. Incubating HAoEC with BMS CCR2 22 before MCP-1 dramatically enhanced VCAM-1 and PECAM1 cell surface levels (from 72.8% to 160% and from 97.2% to 127%, respectively) [3].
|
|---|---|
| References |
|
| Molecular Formula |
C28H34F3N5O4S
|
|---|---|
| Molecular Weight |
593.6662
|
| Exact Mass |
593.228
|
| CAS # |
445479-97-0
|
| PubChem CID |
24801690
|
| Appearance |
White to off-white solid powder
|
| LogP |
6.181
|
| Hydrogen Bond Donor Count |
5
|
| Hydrogen Bond Acceptor Count |
8
|
| Rotatable Bond Count |
9
|
| Heavy Atom Count |
41
|
| Complexity |
914
|
| Defined Atom Stereocenter Count |
2
|
| SMILES |
CC(C)NC(=O)NC1=C(C=C(C=C1)C(F)(F)F)C(=O)NCC(=O)N[C@H]2CCCC[C@H]2NC(=O)C3=CC=C(C=C3)SC
|
| InChi Key |
IBPXYDUJQWENPM-XZOQPEGZSA-N
|
| InChi Code |
InChI=1S/C28H34F3N5O4S/c1-16(2)33-27(40)36-21-13-10-18(28(29,30)31)14-20(21)26(39)32-15-24(37)34-22-6-4-5-7-23(22)35-25(38)17-8-11-19(41-3)12-9-17/h8-14,16,22-23H,4-7,15H2,1-3H3,(H,32,39)(H,34,37)(H,35,38)(H2,33,36,40)/t22-,23+/m0/s1
|
| Chemical Name |
N-[2-[[(1S,2R)-2-[(4-methylsulfanylbenzoyl)amino]cyclohexyl]amino]-2-oxoethyl]-2-(propan-2-ylcarbamoylamino)-5-(trifluoromethyl)benzamide
|
| Synonyms |
BMS-22BMS22 BMS CCR-2 22 BMS CCR2 22
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~250 mg/mL (~421.12 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (3.50 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.6844 mL | 8.4222 mL | 16.8444 mL | |
| 5 mM | 0.3369 mL | 1.6844 mL | 3.3689 mL | |
| 10 mM | 0.1684 mL | 0.8422 mL | 1.6844 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
|
|
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
