| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| Other Sizes |
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| ln Vitro |
BMS-191011 (20 or 40 µM) causes potentiation in Panc-1 cells and opens BK channels in IGR39 cells [3].
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|---|---|
| ln Vivo |
Rat retinal arterioles are dilated by BMS-191011 (iv; 10-100 µg/kg; once) through in vivo activation of iberiotoxin-sensitive BK(Ca) channels [2].
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| Cell Assay |
Cell Viability Assay[3]
Cell Types: IGR39 and Panc-1 Cell Tested Concentrations: 20 or 40 µM Incubation Duration: Experimental Results: Activation of BK channels in less than 50% of IGR39 cells and less than twice as high in Panc-1 cells of enhancement. Promotes activation of voltage-independent K+ conductance at negative voltages. |
| Animal Protocol |
Animal/Disease Models: Male Wistar rats (8 to 10 weeks old) were treated with tetrodotoxin (50 µg/kg, intravenously (iv) (iv)(iv) (iv)) [2]
Doses: 10-100 µg/kg Route of Administration: intravenously (iv) (iv)(iv); i.v. injection. 10-100 micrograms/kg; primary Experimental Results:the diameter of retinal arterioles increases, but has no significant effect on mean arterial pressure and heart rate. |
| References |
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| Additional Infomation |
3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-one is a member of (trifluoromethyl)benzenes.
|
| Molecular Formula |
C16H10CLF3N2O3
|
|---|---|
| Molecular Weight |
370.71
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| Exact Mass |
370.033
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| Elemental Analysis |
C, 51.84; H, 2.72; Cl, 9.56; F, 15.37; N, 7.56; O, 12.95
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| CAS # |
202821-81-6
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| PubChem CID |
10474339
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| Appearance |
White to off-white solid powder
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| Density |
1.516g/cm3
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| Boiling Point |
443.965ºC at 760 mmHg
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| Flash Point |
222.302ºC
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| Vapour Pressure |
0mmHg at 25°C
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| Index of Refraction |
1.598
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| LogP |
3.929
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
7
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
25
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| Complexity |
535
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| Defined Atom Stereocenter Count |
0
|
| InChi Key |
QKOWACXSXTXRKA-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C16H10ClF3N2O3/c17-12-5-6-13(23)10(7-12)8-22-15(24)25-14(21-22)9-1-3-11(4-2-9)16(18,19)20/h1-7,23H,8H2
|
| Chemical Name |
3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-one
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| Synonyms |
BMS 191011 BMS191011BMS-191011 UNII-LW7MXS978N Bms-a
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~125 mg/mL (~337.19 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (5.61 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (5.61 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6975 mL | 13.4876 mL | 26.9753 mL | |
| 5 mM | 0.5395 mL | 2.6975 mL | 5.3951 mL | |
| 10 mM | 0.2698 mL | 1.3488 mL | 2.6975 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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