| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| Other Sizes |
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| ln Vitro |
Neoparamiba parasites are toxic to dithiol sulfoxide (0.1–10 mg/mL, 72 hours) in seawater [1]. Dithiol sulfoxide (1-1000 μg/plate) shows carcinogenic activity in strains TA98 and TA100 (in a Salmonella/mammalian microsome test) in the absence of metabolic activation [5].
|
|---|---|
| ln Vivo |
Oral dithiol sulfoxide has LD50 values of 1000–5000 mg/kg for mice and roughly 5000 mg/kg for rats; at high dosages (5000–100 mg/kg), serum AST is elevated [3]. Dairy cows that naturally contract ruminal fluke infections can benefit from oral dithiol sulfoxide at doses of 80 and 90 mg/kg [4].
|
| Animal Protocol |
Animal/Disease Models: Cow [4]
Doses: 60, 80, 90 mg/kg Route of Administration: Oral Experimental Results: After 1 week of treatment, the efficacy against ruminal fluke infection was approximately 70% at doses of 80 and 90 mg/kg . |
| References |
[1]. Florent RL, et al. In vitro toxicity of bithionol and bithionol sulphoxide to Neoparamoeba spp., the causative agent of amoebic gill disease (AGD). Dis Aquat Organ. 2010 Sep 17;91(3):257-62.
[2]. S P Yang, et al. Treatment of paragonimiasis with bithionol and bithionol sulfoxide. Dis Chest. 1967 Aug;52(2):220-32. [3]. Lavrič A, et al. Oral toxicity of bithionol sulfoxide in mice and rats. Zbornik Veterinarske Fakultete Univerza Ljubljana 1990 Vol.27 No.1 pp.33-39 ref.22. [4]. Chompoochan T, et al. The anthelmintic effects of bithionol sulfoxide against sheep experimentally infected with Fasciola gigantica[C]//ACIAR PROCEEDINGS. 1996: 189-194. [5]. D.Mourot, et al. Mutagenicity of bithionol sulfoxide and its metabolites in the Salmonella/mammalian microsome test. Mutation Research/Genetic Toxicology, 1987, 188(1): 53-55. |
| Molecular Formula |
C12H6O3SCL4
|
|---|---|
| Molecular Weight |
372.05124
|
| Exact Mass |
369.879
|
| CAS # |
844-26-8
|
| Related CAS # |
Bithionol;97-18-7
|
| PubChem CID |
68939
|
| Appearance |
White to off-white solid powder
|
| Density |
1.86 g/cm3
|
| Boiling Point |
532.7ºC at 760 mmHg
|
| Flash Point |
276ºC
|
| Index of Refraction |
1.769
|
| LogP |
5.743
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
20
|
| Complexity |
341
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O=S(C1C(O)=C(Cl)C=C(Cl)C=1)C1C(O)=C(Cl)C=C(Cl)C=1
|
| InChi Key |
RPAJWWXZIQJVJF-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C12H6Cl4O3S/c13-5-1-7(15)11(17)9(3-5)20(19)10-4-6(14)2-8(16)12(10)18/h1-4,17-18H
|
| Chemical Name |
2,4-dichloro-6-(3,5-dichloro-2-hydroxyphenyl)sulfinylphenol
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ≥ 250 mg/mL (~671.95 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (5.59 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.08 mg/mL (5.59 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (5.59 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6878 mL | 13.4391 mL | 26.8781 mL | |
| 5 mM | 0.5376 mL | 2.6878 mL | 5.3756 mL | |
| 10 mM | 0.2688 mL | 1.3439 mL | 2.6878 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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