| Size | Price | Stock | Qty |
|---|---|---|---|
| 25mg |
|
||
| 50mg |
|
||
| Other Sizes |
| Targets |
Avidin (and streptavidin). Biotin sulfone binds to avidin with a binding ratio of 0.332 compared with biotin. It is an endogenous metabolite.
|
|---|---|
| ln Vitro |
Biotin sulfone binds to avidin with a binding ratio of 0.332 compared with biotin. As a metabolite of biotin, its function is related to that of biotin sulfoxide.
|
| ln Vivo |
Biotin sulfone is first isolated as a natural metabolite of biotin. It has been used to immobilize oligosaccharides on avidin-coated surfaces for the detection of anti-C. albicans antibodies.
|
| Enzyme Assay |
In vitro binding assays for Biotin sulfone involve measuring its affinity for avidin or streptavidin using surface plasmon resonance or ELISA-based methods. The binding ratio is determined by comparing its binding to that of biotin.
|
| Cell Assay |
The in vitro cellular activity of Biotin sulfone is not typically studied, as it is a metabolite and a biochemical reagent. It may be used in cell-based assays to study biotin metabolism or as a tool for immobilization applications.
|
| Animal Protocol |
No specific in vivo animal experimental protocols are available for Biotin sulfone. As a metabolite of biotin, it is studied in the context of biotin metabolism and disposition. Animal studies involving biotin administration may include measurement of biotin sulfone levels.
|
| ADME/Pharmacokinetics |
Biotin sulfone has a molecular formula of C10H16N2O5S and a molecular weight of 276.31. It is an oxidized form of biotin. IUPAC name: 5-((3aS,4S,6aR)-5,5-dioxido-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid.
|
| Toxicity/Toxicokinetics |
No specific toxicological data is available for Biotin sulfone. As a metabolite of biotin, it is expected to have low toxicity. Standard laboratory safety precautions should be observed.
|
| References | |
| Additional Infomation |
Biotin sulfone is a type of biotinylate compound with a structure similar to biotin sulfoxide, except that the sulfoxide group is replaced by a sulfone group. It is a metabolite belonging to both biotin and sulfone compounds, and its function is related to that of biotin sulfoxide. Biotin sulfone has been reported in Trypanosoma brevicornu, and relevant data are available for reference.
Biotin sulfone is an oxidized form of biotin and a natural metabolite. It binds to avidin with a binding ratio of 0.332 compared with biotin and has been used to immobilize oligosaccharides. It is not approved for clinical use and is intended for research purposes only. |
| Molecular Formula |
C10H16N2O5S
|
|---|---|
| Molecular Weight |
276.30900
|
| Exact Mass |
276.078
|
| CAS # |
40720-05-6
|
| PubChem CID |
83863
|
| Appearance |
White to off-white solid powder
|
| Density |
1.382g/cm3
|
| Boiling Point |
706.7ºC at 760 mmHg
|
| Flash Point |
381.2ºC
|
| Index of Refraction |
1.533
|
| LogP |
1.216
|
| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
5
|
| Heavy Atom Count |
18
|
| Complexity |
455
|
| Defined Atom Stereocenter Count |
3
|
| SMILES |
C1[C@H]2[C@@H]([C@@H](S1(=O)=O)CCCCC(=O)O)NC(=O)N2
|
| InChi Key |
QPFQYMONYBAUCY-ZKWXMUAHSA-N
|
| InChi Code |
InChI=1S/C10H16N2O5S/c13-8(14)4-2-1-3-7-9-6(5-18(7,16)17)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1
|
| Chemical Name |
5-[(3aS,4S,6aR)-2,5,5-trioxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~250 mg/mL (~904.78 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (7.53 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (7.53 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (7.53 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6191 mL | 18.0956 mL | 36.1912 mL | |
| 5 mM | 0.7238 mL | 3.6191 mL | 7.2382 mL | |
| 10 mM | 0.3619 mL | 1.8096 mL | 3.6191 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
