| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
|
||
| 100mg |
|
||
| 250mg |
|
||
| 500mg |
|
||
| Other Sizes |
|
| ln Vitro |
On β2-adrenergic receptors, bevanol hydrochloride has a pKi of 6.23[1].
|
|---|---|
| ln Vivo |
The expression level of β1-adrenergic receptor mRNA can be considerably reduced by bevanol hydrochloride (200 mg/kg; oral; for 6 weeks) [2].
|
| Animal Protocol |
Animal/Disease Models: Male Wistar rats, body weight 250-300 g [2]
Doses: 200 mg/kg Route of Administration: Oral administration with water; lasted for 6 weeks. Experimental Results: The expression level of β1 adrenergic receptor mRNA was Dramatically diminished. |
| References |
|
| Molecular Formula |
C20H28CLNO4
|
|---|---|
| Molecular Weight |
381.8936
|
| Exact Mass |
381.17
|
| CAS # |
42864-78-8
|
| Related CAS # |
Bevantolol;59170-23-9
|
| PubChem CID |
39324
|
| Appearance |
White to off-white solid powder
|
| Boiling Point |
518.3°C
|
| LogP |
3.777
|
| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
10
|
| Heavy Atom Count |
26
|
| Complexity |
355
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
FJTKCFSPYUMXJB-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C20H27NO4.ClH/c1-15-5-4-6-18(11-15)25-14-17(22)13-21-10-9-16-7-8-19(23-2)20(12-16)24-3;/h4-8,11-12,17,21-22H,9-10,13-14H2,1-3H3;1H
|
| Chemical Name |
1-[2-(3,4-dimethoxyphenyl)ethylamino]-3-(3-methylphenoxy)propan-2-ol;hydrochloride
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~62.5 mg/mL (~163.66 mM)
H2O : ~4.55 mg/mL (~11.91 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 6.25 mg/mL (16.37 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6186 mL | 13.0928 mL | 26.1856 mL | |
| 5 mM | 0.5237 mL | 2.6186 mL | 5.2371 mL | |
| 10 mM | 0.2619 mL | 1.3093 mL | 2.6186 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
