| Size | Price | Stock | Qty |
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| 50mg |
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| 100mg |
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| ln Vitro |
Among the many biological and pharmacological characteristics of betulin (BE), its anticancer and chemopreventive actions have garnered a lot of interest. It has been demonstrated that BE inhibits phospholipid growth to produce anti-cancer effects. With IC50 values ranging from 2.8 to 3.4 μM, consistent with established significantly reduced compared to the cell lines, BE was found to exhibit quite different antiproliferative activities depending on the type of cell, ranging from a weak inhibition of cell proliferation of a human erythroid cell line (K562) to a strong inhibition of human neuroblastoma (SK-N-AS). Moreover, significant toxicity was also observed in primary liver cancer cultures isolated from specimen tumors of patients with ovarian cancer, cervical cancer, and astroblastoma. The cytotoxic activity of human (EPG85-257) and human pancreatic cancer (EPP85-181) drug-sensitive and complementary (daunorubicin and mitoxantrone) cell lines was compared using crude birch bark extract, contracted betulin, and betulinic acid [1]. Depending on the molecule utilized, there are notable changes between cell lines per se, indicating that both betulinic acid and betulinic acid may be considered potential leads for the treatment of cancer [2].
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| ln Vivo |
Betulin dramatically changed basic learning performance and improved intolerance. Bentolin treatment dramatically decreased the amount of MDA in the hippocampal tissue and increased SOD activity. Additionally, betulin markedly lowered the hippocampal and serum levels of inflammatory cytokines. Furthermore, BE treatment successfully inhibited NF-κB and IκB phosphorylation while upregulating the levels of Nrf2 and HO-1. In conclusion, BE may prevent STZ-induced diabetic rats' cognitive deterioration by loading HO-1/Nrf-2/NF-κB [3].
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| References | |
| Additional Infomation |
Betulin is a pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents. It has a role as a metabolite, an antiviral agent, an analgesic, an anti-inflammatory agent and an antineoplastic agent. It is a pentacyclic triterpenoid and a diol. It derives from a hydride of a lupane.
Betulin has been reported in Acanthus ilicifolius, Bowdichia virgilioides, and other organisms with data available. |
| Molecular Formula |
C30H50O2
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|---|---|
| Molecular Weight |
442.72
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| Exact Mass |
442.381
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| CAS # |
473-98-3
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| PubChem CID |
72326
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| Appearance |
White to off-white solid powder
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| Density |
1.0±0.1 g/cm3
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| Boiling Point |
522.3±23.0 °C at 760 mmHg
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| Melting Point |
256-257 °C(lit.)
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| Flash Point |
210.9±17.2 °C
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| Vapour Pressure |
0.0±3.1 mmHg at 25°C
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| Index of Refraction |
1.525
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| LogP |
9.01
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
32
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| Complexity |
786
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| Defined Atom Stereocenter Count |
10
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| SMILES |
CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)CO
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| InChi Key |
FVWJYYTZTCVBKE-ROUWMTJPSA-N
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| InChi Code |
InChI=1S/C30H50O2/c1-19(2)20-10-15-30(18-31)17-16-28(6)21(25(20)30)8-9-23-27(5)13-12-24(32)26(3,4)22(27)11-14-29(23,28)7/h20-25,31-32H,1,8-18H2,2-7H3/t20-,21+,22-,23+,24-,25+,27-,28+,29+,30+/m0/s1
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| Chemical Name |
Lup-20(29)-ene-3β,28-diol
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| Synonyms |
TrocholBetulinAI3-62999 BetulolBetulinolBetuline
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~3.33 mg/mL (~7.52 mM)
H2O : < 0.1 mg/mL |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 0.2 mg/mL (0.45 mM) (saturation unknown) in 5% DMSO + 40% PEG300 + 5% Tween80 + 50% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 0.2 mg/mL (0.45 mM) (saturation unknown) in 5% DMSO + 95% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. View More
Solubility in Formulation 3: 3 mg/mL (6.78 mM) in 50% PEG300 50% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2588 mL | 11.2938 mL | 22.5876 mL | |
| 5 mM | 0.4518 mL | 2.2588 mL | 4.5175 mL | |
| 10 mM | 0.2259 mL | 1.1294 mL | 2.2588 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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